Mori Y, Wada H, Nagano Y, Deguchi K, Kita T, Shirakawa S
Second Department of Internal Medicine, Faculty of Medicine, Mie University, Japan.
Thromb Haemost. 1989 Feb 28;61(1):140-3.
Blood coagulation in a strain of rabbits designated as Watanabe heritable hyperlipidemic (WHHL) rabbits was examined. The activities of vitamin K-dependent clotting factors, contact factors and clotting factor VIII (F VIII) and the fibrinogen level were significantly higher in WHHL rabbits than in normolipidemic rabbits (all age groups). Values for vitamin K-dependent clotting factor were already higher at 2 months of age. Contact factors and fibrinogen levels increased age after 5 to 8 months. F VIII increased between 5 and 8 months and then decreased. At 2 months of age, WHHL rabbits were divided into two groups. Group A was fed standard rabbit chow and group B standard rabbit chow containing 1% probucol. Probucol prevented the progression of atherosclerosis in group B in the absence of a significant reduction in plasma cholesterol level. F VIII and fibrinogen levels were statistically decreased in all rabbits at all ages in group B (P less than 0.05). These differences in clotting factors between the two groups were most obvious at 8 months (P less than 0.02). We conclude that vitamin K-dependent clotting factors may increase with hyperlipemia and that increases in F VIII and fibrinogen may be closely related to the progression of thromboatherosclerosis.
对一种名为渡边遗传性高脂血症（WHHL）兔的凝血情况进行了检测。在WHHL兔中，维生素K依赖凝血因子、接触因子、凝血因子VIII（F VIII）的活性以及纤维蛋白原水平显著高于正常血脂兔（所有年龄组）。维生素K依赖凝血因子的数值在2月龄时就已较高。接触因子和纤维蛋白原水平在5至8月龄后随年龄增长而升高。F VIII在5至8月龄时升高，之后下降。在2月龄时，将WHHL兔分为两组。A组喂标准兔饲料，B组喂含1%普罗布考的标准兔饲料。普罗布考在不显著降低血浆胆固醇水平的情况下阻止了B组动脉粥样硬化的进展。B组所有年龄的所有兔子的F VIII和纤维蛋白原水平均有统计学意义的降低（P<0.05）。两组之间凝血因子的这些差异在8月龄时最为明显（P<0.02）。我们得出结论，维生素K依赖凝血因子可能随高脂血症而增加，F VIII和纤维蛋白原的增加可能与血栓性动脉粥样硬化的进展密切相关。
