Department of Veterinary Medicine, Ethics and Jurisprudence, Faculty of Veterinary and Animal Sciences, West Bengal University of Animal and Fishery Sciences, Kolkata, India.
J. B. Roy State Ayurvedic Medical College and Hospital, West Bengal University of Health Sciences, Kolkata 700004, West Bengal, India.
J Ethnopharmacol. 2017 Feb 2;197:266-273. doi: 10.1016/j.jep.2016.07.079. Epub 2016 Aug 3.
Chronic arsenic poisoning due to contaminated subsoil water is a threat to society in West Bengal, India and in Bangladesh. The human being may also be affected by the exposed cattle from the affected area by consuming milk, egg, meat and others. In Ayurveda, several herbs like Haridra (turmeric), Shunthi (dried ginger root) and others are used for the management of arsenic poisoning.
The study was conducted to find out the ameliorative effect of turmeric and ginger powder against experimentally induced arsenic toxicity in calves.
Twenty four calves were divided into four groups (group I, II, III and IV) having six animals in each group. Animals of group I, II and III were orally administered with sodium arsenite at 1mg/kg body weight for 90 days and in addition group II and group III animals were treated orally with turmeric and ginger powder respectively at 10mg/kg body weight from 46th day onwards. Group IV animals were given food and water without drug and served as control. Arsenic content was estimated in faeces, hair, urine and plasma in every 15 days. Bio-chemical, haematological and anti-oxidant parameters were also assessed.
Turmeric and ginger powder significantly (P<0.05) reduced the plasma and hair arsenic levels through increased excretion via faeces and urine. Haemoglobin level, TEC and TLC were decreased in groups I, II and III, however these were improved significantly (P<0.05) from 75th day onwards in turmeric and ginger treated groups. Increased activity of AST and ALT were significantly decreased (P<0.05) from 75th day onwards in group II and III. Blood urea nitrogen and plasma creatinine were also significantly decreased (P<0.05) in group II and III than group I from 60th day onwards. The SOD and catalase activity were significantly (P<0.05) reduced in groups I, II and III, but these were restored at the end of the experiment in turmeric and ginger treated groups.
The test drugs are found significantly effective not only to eliminate arsenic from the body but also give protection from possible damage caused by arsenic exposure, it may be concluded from the present study that turmeric and ginger can be helpful in the therapy of chronic arsenic toxicity in calves.
由于受污染的底土水导致的慢性砷中毒是印度西孟加拉邦和孟加拉国社会面临的威胁。人类也可能通过食用受影响地区的牛奶、鸡蛋、肉类等暴露的牛而受到影响。在阿育吠陀医学中，有几种草药，如 Haridra（姜黄）、Shunthi（干姜根）等，用于治疗砷中毒。
本研究旨在发现姜黄和生姜粉对小牛实验性砷毒性的改善作用。
将 24 头小牛分为四组（I、II、III 和 IV 组），每组 6 头。I、II 和 III 组动物每天口服亚砷酸钠 1mg/kg 体重，共 90 天；此外，II 组和 III 组动物从第 46 天开始分别口服姜黄和生姜粉 10mg/kg 体重。IV 组动物给予无药物的食物和水，作为对照。每 15 天评估粪便、毛发、尿液和血浆中的砷含量。还评估了生化、血液学和抗氧化参数。
姜黄和生姜粉通过增加粪便和尿液排泄，显著（P<0.05）降低了血浆和毛发中的砷含量。I、II 和 III 组的血红蛋白水平、TEC 和 TLC 降低，但从第 75 天开始，在姜黄和生姜处理组中，这些指标显著（P<0.05）改善。AST 和 ALT 的活性从第 75 天开始显著（P<0.05）降低在 II 组和 III 组中。从第 60 天开始，II 组和 III 组的血尿素氮和血浆肌酐也显著（P<0.05）降低。I、II 和 III 组的 SOD 和过氧化氢酶活性显著（P<0.05）降低，但在姜黄和生姜处理组中，在实验结束时恢复。
试验药物不仅能有效地从体内消除砷，而且能防止砷暴露造成的可能损害，从本研究可以得出结论，姜黄和生姜可用于治疗小牛慢性砷中毒。
