Karim Md Rezaul, Haque Abedul, Islam Khairul, Ali Nurshad, Salam Kazi Abdus, Saud Zahangir Alam, Hossain Ekhtear, Fajol Abul, Akhand Anwarul Azim, Himeno Seiichiro, Hossain Khaled
Department of Applied Nutrition and Food Technology, Islamic University, Kushtia-7003, Bangladesh.
Bangladesh Med Res Counc Bull. 2010 Dec;36(3):82-8. doi: 10.3329/bmrcb.v36i3.7287.
The present study was undertaken to evaluate the protective effect of turmeric powder on arsenic toxicity through mice model. Swiss albino male mice were divided into four groups. The first group was used as control, while groups 2, 3, and 4 were treated with turmeric powder (T, 50 mg/kg body weight/day), sodium arsenite (Sa, 10 mg/kg body weight/day) and turmeric plus Sa (T+Sa), respectively. Results showed that oral administration of Sa reduced the weight gain of the mice compared to the control group and food supplementation of turmeric prevented the reduction of weight gain. Turmeric abrogated the Sa-induced elevation of serum urea, glucose, triglyceride (TG) level and alanine aminotransferase (ALT) activity except the activity of alkaline phosphatase (ALP). Turmeric also prevented the Sa-induced perturbation of serum butyryl cholinesterase activity (BChE). Therefore, ameliorating effect of turmeric on Sa-treated mice suggested the future application of turmeric to reduce or to prevent arsenic toxicity in human.
本研究旨在通过小鼠模型评估姜黄粉对砷毒性的保护作用。将瑞士白化雄性小鼠分为四组。第一组作为对照组，而第2、3和4组分别用姜黄粉（T，50毫克/千克体重/天）、亚砷酸钠（Sa，10毫克/千克体重/天）和姜黄加Sa（T+Sa）处理。结果表明，与对照组相比，口服Sa降低了小鼠的体重增加，而补充姜黄粉可防止体重增加的减少。除碱性磷酸酶（ALP）活性外，姜黄消除了Sa诱导的血清尿素、葡萄糖、甘油三酯（TG）水平和丙氨酸转氨酶（ALT）活性的升高。姜黄还预防了Sa诱导的血清丁酰胆碱酯酶活性（BChE）的紊乱。因此，姜黄对Sa处理小鼠的改善作用表明姜黄在未来可用于减少或预防人类的砷毒性。
