Richer Martin J, Lang Mark L, Butler Noah S
Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3A 2B4, Canada; Microbiome and Disease Tolerance Centre, McGill University, Montreal, Quebec H3A 2B4, Canada;
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Graduate Program in Biosciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104.
J Immunol. 2016 Aug 15;197(4):1009-15. doi: 10.4049/jimmunol.1600847.
Recent data illustrate a key role for the transcriptional regulator bric-a-brac, tramtrack, and broad complex and cap'n'collar homology (Bach)2 in orchestrating T cell differentiation and function. Although Bach2 has a well-described role in B cell differentiation, emerging data show that Bach2 is a prototypical member of a novel class of transcription factors that regulates transcriptional activity in T cells at super-enhancers, or regions of high transcriptional activity. Accumulating data demonstrate specific roles for Bach2 in favoring regulatory T cell generation, restraining effector T cell differentiation, and potentiating memory T cell development. Evidence suggests that Bach2 regulates various facets of T cell function by repressing other key transcriptional regulators such as B lymphocyte-induced maturation protein 1. In this review, we examine our present understanding of the role of Bach2 in T cell function and highlight the growing evidence that this transcriptional repressor functions as a key regulator involved in maintenance of T cell quiescence, T cell subset differentiation, and memory T cell generation.
近期数据表明，转录调节因子bric-a-brac、tramtrack和broad complex以及cap'n'collar同源物（Bach）2在协调T细胞分化和功能方面发挥着关键作用。尽管Bach2在B细胞分化中具有明确的作用，但新出现的数据表明，Bach2是一类新型转录因子的典型成员，这类转录因子在超级增强子或高转录活性区域调节T细胞中的转录活性。越来越多的数据表明，Bach2在促进调节性T细胞生成、抑制效应T细胞分化以及增强记忆性T细胞发育方面具有特定作用。有证据表明，Bach2通过抑制其他关键转录调节因子（如B淋巴细胞诱导的成熟蛋白1）来调节T细胞功能的各个方面。在这篇综述中，我们审视了目前对Bach2在T细胞功能中作用的理解，并强调了越来越多的证据表明，这种转录抑制因子作为关键调节因子，参与维持T细胞静止、T细胞亚群分化以及记忆性T细胞生成。
