The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79# Qingchun Road, 6A-5, Hangzhou, 310003, China.
Cell Commun Signal. 2024 Mar 8;22(1):169. doi: 10.1186/s12964-024-01551-8.
Bach2 was initially discovered in B cells, where it was revealed to control the transcription involved in cell differentiation. Bach2 is intimately connected to CD8 + T lymphocytes in various differentiation states and subsets according to recent findings. Bach2 can regulate primitive T cells, stimulate the development and differentiation of memory CD8 + T cells, inhibit the differentiation of effector CD8 + T cells, and play a significant role in the exhaustion of CD8 + T cells. The appearance and development of diseases are tightly linked to irregular CD8 + T cell differentiation and function. Accordingly, Bach2 offers novel approaches and possible targets for the clinical treatment of associated disorders based on research on these pathways. Here, we summarize the role of Bach2 in the function and differentiation of CD8 + T cells and its potential clinical applications.
Bach2 最初在 B 细胞中被发现，其被揭示可控制细胞分化过程中涉及的转录。根据最近的研究发现，Bach2 与各种分化状态和亚群的 CD8+T 淋巴细胞密切相关。Bach2 可以调节原始 T 细胞，刺激记忆 CD8+T 细胞的发育和分化，抑制效应 CD8+T 细胞的分化，并在 CD8+T 细胞耗竭中发挥重要作用。疾病的发生和发展与 CD8+T 细胞分化和功能的异常密切相关。因此，基于对这些通路的研究，Bach2 为相关疾病的临床治疗提供了新的方法和可能的靶点。在这里，我们总结了 Bach2 在 CD8+T 细胞功能和分化中的作用及其潜在的临床应用。
