Saillenfait A M, Bonnet P, Guenier J P, de Ceaurriz J
Institut National de Recherche et de Sécurité, Vandoeuvre, France.
Toxicol Lett. 1989 Jun;47(3):235-40. doi: 10.1016/0378-4274(89)90141-0.
Pregnant rats were exposed to 0, 2, 5, 10 or 15 ppm hexachloro-1,3-butadiene (HCBD) 6 h/d during days 6-20 of gestation. Maternal reproduction and fetal parameters were evaluated on gestational day 21. A significant reduction in maternal weight gain and in fetal body weight occurred at 15 ppm. The incidences of external, visceral and skeletal alterations were not significantly increased in any of the HCBD-exposed groups. It is concluded that exposure of pregnant rats to HCBD by inhalation of concentrations high enough to cause maternal and slight fetal toxicity is neither embryotoxic nor teratogenic.
在妊娠第6至20天，将怀孕大鼠每天暴露于0、2、5、10或15 ppm的六氯-1,3-丁二烯（HCBD）中6小时。在妊娠第21天评估母体生殖和胎儿参数。15 ppm时母体体重增加和胎儿体重显著降低。在任何暴露于HCBD的组中，外部、内脏和骨骼改变的发生率均未显著增加。得出的结论是，怀孕大鼠吸入足以引起母体和轻微胎儿毒性的高浓度HCBD既不会产生胚胎毒性也不会产生致畸性。
