Bai C L, Canfield P J, Stacey N H
National Institute of Occupational Health and Safety, Worksafe Australia, Sydney, NSW.
Toxicol Ind Health. 1992 May-Jun;8(3):191-203. doi: 10.1177/074823379200800305.
Rats were exposed to hexachlorobutadiene (HCBD) or tetrachloroethylene (TET) in order to determine which of these chemicals was more likely to be responsible for elevations in individual serum bile acids (SBA) found in workers exposed primarily to these two chemicals. Increases in cholic and taurocholic acids were found on exposure to high doses of HCBD. Elevations of SBA occurred right down to low exposures for TET, however, with cholic, chenodeoxycholic, and glycocholic acids being the most sensitive bile acids. Only at high doses for each chemical was there any indication of liver injury as determined by routinely used parameters such as serum enzymes or bilirubin. The data suggest that TET is likely to play a role in the elevated individual SBA in an exposure situation where both this chemical and HCBD are found.
将大鼠暴露于六氯丁二烯（HCBD）或四氯乙烯（TET）中，以确定这两种化学物质中哪一种更有可能是导致主要接触这两种化学物质的工人个体血清胆汁酸（SBA）升高的原因。暴露于高剂量的HCBD时，发现胆酸和牛磺胆酸增加。然而，对于TET，即使低剂量暴露也会导致SBA升高，其中胆酸、鹅去氧胆酸和甘胆酸是最敏感的胆汁酸。只有在每种化学物质的高剂量下，通过血清酶或胆红素等常规使用的参数才能确定有任何肝损伤迹象。数据表明，在同时存在这种化学物质和HCBD的暴露情况下，TET可能在个体SBA升高方面起作用。
