Novotna Klara, Sobisek Lukas, Horakova Dana, Havrdova Eva, Lizrova Preiningerova Jana
Department of Neurology and Centre of Clinical Neuroscience, First School of Medicine and General University Hospital, Charles University in Prague, Prague, Czech Republic.
Eur Neurol. 2016;76(3-4):99-104. doi: 10.1159/000448091. Epub 2016 Aug 6.
Gait impairment is a common symptom in multiple sclerosis (MS) patients, but there is a lack of evidence about gait performance in the group of MS patients with no apparent disability. The aim of our study was to evaluate gait characteristics in MS patients with no apparent impairment of walking and with an Expanded Disability Status Scale (EDSS 0-1.5), and to determine whether any abnormalities are detectable by common clinical tests.
This was an observational study of 64 MS patients with an EDSS 0-1.5 and 47 age- and sex-matched healthy controls. We measured their performance in the timed 25-foot walk test (T25FWT) and the 2-minute walk test (2MWT). The spatiotemporal parameters of gait were measured using a GAITRite instrument.
MS patients with no apparent disability (EDSS 0-1.5) performed worse in T25FWT and 2MWT than normal controls. During the self-selected walking speed test on GAITRite, MS patients had a prolonged double support phase, and during the fast walking speed test, they had lower cadence and decreased step length.
步态障碍是多发性硬化症（MS）患者的常见症状，但对于无明显残疾的MS患者群体的步态表现，缺乏相关证据。我们研究的目的是评估步行无明显受损且扩展残疾状态量表（EDSS 0 - 1.5）评分的MS患者的步态特征，并确定通过常规临床检查是否能检测到任何异常。
这是一项对64例EDSS评分为0 - 1.5的MS患者以及47例年龄和性别匹配的健康对照者的观察性研究。我们测量了他们在25英尺定时步行测试（T25FWT）和2分钟步行测试（2MWT）中的表现。使用GAITRite仪器测量步态的时空参数。
无明显残疾（EDSS 0 - 1.5）的MS患者在T25FWT和2MWT中的表现比正常对照者差。在GAITRite上的自选步行速度测试中，MS患者的双支撑期延长，在快速步行速度测试中，他们的步频较低且步长减小。
