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嗜鱼外瓶霉:变应性支气管肺真菌病的一种新病因。

Exophiala pisciphila: a novel cause of allergic bronchopulmonary mycosis.

作者信息

Kebbe Jad, Mador M Jeffery

机构信息

Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA.

出版信息

J Thorac Dis. 2016 Jul;8(7):E538-41. doi: 10.21037/jtd.2016.05.77.

Abstract

Allergic bronchopulmonary mycosis (ABPM) is a hypersensitivity reaction to fungal antigens, which may particularly plague uncontrolled asthmatics. Non-aspergillus fungal organisms may be implicated and may elicit a more severe immunologic response. Exophiala pisciphila, a marine organism, has not been reported as a culprit yet. However, this report indicates it may be implicated in unrelenting symptoms in a severe asthmatic patient who had become dependent on corticosteroids. Proper identification and adequate therapy of this organism led to complete resolution of respiratory symptoms, with adequate subsequent control of the asthma. ABPM may complicate asthma and lead to a lack of its control. Proper awareness, testing and treatment of non-aspergillus pulmonary mycosis is essential to proper asthma care and beneficial for its control.

摘要

变应性支气管肺真菌病(ABPM)是对真菌抗原的一种超敏反应,这可能特别困扰未得到控制的哮喘患者。非曲霉菌真菌生物可能与此有关,并且可能引发更严重的免疫反应。嗜鱼外瓶霉是一种海洋生物,尚未被报道为致病原。然而,本报告表明,它可能与一名严重哮喘患者的持续症状有关,该患者已对皮质类固醇产生依赖。对这种生物的正确识别和充分治疗导致呼吸道症状完全缓解,随后哮喘得到充分控制。ABPM可能使哮喘复杂化并导致其控制不佳。对非曲霉菌肺真菌病的正确认识、检测和治疗对于哮喘的恰当护理至关重要,且有利于哮喘的控制。

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