白细胞介素-6基因多态性与中国2型糖尿病患者肾病进展的相关性：一项前瞻性队列研究。
Interleukin-6 gene polymorphisms correlate with the progression of nephropathy in Chinese patients with type 2 diabetes: A prospective cohort study.
作者信息
Chang Wen-Tsan, Huang Meng-Chuan, Chung Hsin-Fang, Chiu Yen-Feng, Chen Pao-Shan, Chen Fang-Pei, Lee Chun-Yi, Shin Shyi-Jang, Hwang Shang-Jyh, Huang Ya-Fang, Hsu Chih-Cheng
机构信息
Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Department of Public Health and Environmental Science and Graduate Institute of Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Nutrition and Dietetics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
出版信息
Diabetes Res Clin Pract. 2016 Oct;120:15-23. doi: 10.1016/j.diabres.2016.07.013. Epub 2016 Jul 28.
AIMS
Interleukin-6 (IL-6), an inflammatory cytokine, is considered a candidate gene possibly involved in susceptibility to nephropathy in diabetes. This study aimed to examine whether IL-6 polymorphisms predict the progression of nephropathy in a prospective Chinese cohort of patients with type 2 diabetes.
METHODS
A total of 568 type 2 diabetic patients with normoalbuminuria at baseline were followed up for a mean of 5.3±1.5years. Urinary albumin-to-creatinine ratio (ACR) ⩾30mg/g in two consecutive urine tests were defined as progression to diabetic nephropathy (n=143). Five polymorphisms of IL-6 gene, rs1800795, rs1800796, rs1524107, rs2069837, and rs2069840, were genotyped. Cox proportional hazard models were used to estimate hazard ratio (HR) and 95% CI of progression to diabetic nephropathy under different genetic models.
RESULTS
Almost all patients (99.6%) carried the rs1800795 GG homozygous genotypes. In the Cox proportional models adjusted for multiple covariates, the HR under recessive model was 2.02 for rs1800796 GG (vs. CC+CG, 95% CI: 1.08-3.75, p=0.027), 2.37 for rs2069837 GG (vs. AA+AG, 95% CI: 1.15-4.87, p=0.019), and 2.08 for rs1524107 CC (vs. TT+TC, 95% CI: 1.12-3.89, p=0.021). These associations remained significant for rs1800796 and rs1524107 after correction for multiple testing (α=0.017). Overall, our results suggest that rs1800796 GG and rs1524107 CC homozygous genotypes may confer a greater risk for development of nephropathy in type 2 diabetes.
CONCLUSIONS
IL-6 gene polymorphisms rs1800796 and rs1524107 may serve as predictors of progression of nephropathy in Chinese patients with type 2 diabetes.
目的
白细胞介素-6（IL-6）作为一种炎症细胞因子，被认为是可能与糖尿病肾病易感性相关的候选基因。本研究旨在探讨IL-6基因多态性是否能预测中国2型糖尿病患者队列中肾病的进展情况。
方法
共有568例基线时尿白蛋白正常的2型糖尿病患者接受了平均5.3±1.5年的随访。连续两次尿检测中尿白蛋白与肌酐比值（ACR）≥30mg/g被定义为进展为糖尿病肾病（n = 143）。对IL-6基因的5个多态性位点rs1800795、rs1800796、rs1524107、rs2069837和rs2069840进行基因分型。采用Cox比例风险模型估计不同遗传模型下进展为糖尿病肾病的风险比（HR）和95%置信区间（CI）。
结果
几乎所有患者（99.6%）携带rs1800795 GG纯合基因型。在调整了多个协变量的Cox比例模型中，rs1800796 GG的隐性模型下HR为2.02（vs. CC + CG，95% CI：1.08 - 3.75，p = 0.027），rs2069837 GG为2.37（vs. AA + AG，95% CI：1.15 - 4.87，p = 0.019），rs1524107 CC为2.08（vs. TT + TC，95% CI：1.12 - 3.89，p = 0.021）。在多重检验校正后（α = 0.017），rs1800796和rs1524107的这些关联仍然显著。总体而言，我们的结果表明rs1800796 GG和rs1524107 CC纯合基因型可能使2型糖尿病患者发生肾病的风险更高。
结论
IL-6基因多态性rs1800796和rs1524107可能作为中国2型糖尿病患者肾病进展的预测指标。
Zotero 插件