Department of Nephrology and.
Department of Intensive Care Unit, The First Hospital of Jilin University, Changchun, Jilin Province, China.
Am J Med Sci. 2019 Nov;358(5):363-373. doi: 10.1016/j.amjms.2019.07.011. Epub 2019 Jul 31.
The objective of this work was to evaluate the relevance of frequent interleukin-6 (IL-6) polymorphisms and diabetic nephropathy (DN) susceptibility by a systematic meta-analysis.
The included studies related to the relationship between IL-6 and DN risk were searched from Pubmed, Embase and the Cochrane Library, and the Newcastle-Ottawa Scale was used to evaluate the study quality. A heterogeneity test was performed to determine the appropriate effect models based on the Q test and I statistic. Odds ratios with 95% confidence intervals were used to determine the strength of associations. Afterwards, subgroup analysis was conducted to assess the effect of specific factors on the corresponding results. Additionally, publication bias and sensitivity analysis were also undertaken.
In total, 11 eligible articles were obtained. The meta-analysis revealed that the "C"allele of IL-6 rs1800795 was related to the decreased risk of DN (C versus G: P = 0.0471). The "G"allele of IL-6 rs1800796 was predominately associated with higher DN risks (GG versus CC: P = 0.0194; GG versus CC + GC: P = 0.0196). The "C"allele of IL-6 rs1800797 was implicated with higher prevalence of DN (C versus G: P = 0.0001; CC versus GG: P = 0.0003; CC versus GG + CG: P = 0.0227; CC + CG versus GG: P = 0.0001) while IL-6 rs2069837 and rs2069840 were not correlated with the susceptibility to DN.
This meta-analysis indicated that IL-6 rs1800795, rs1800796 and rs1800797 played important roles in DN development while IL-6 rs2069837 and rs2069840 might not be related to DN.
本研究旨在通过系统的荟萃分析评估白细胞介素 6（IL-6）频繁多态性与糖尿病肾病（DN）易感性的相关性。
从 Pubmed、Embase 和 Cochrane Library 中检索与 IL-6 与 DN 风险相关的研究，并使用纽卡斯尔-渥太华量表评估研究质量。根据 Q 检验和 I 统计量进行异质性检验，以确定合适的效应模型。使用比值比及其 95%置信区间来确定关联的强度。然后，进行亚组分析以评估特定因素对相应结果的影响。此外，还进行了发表偏倚和敏感性分析。
共纳入 11 项符合条件的研究。荟萃分析显示，IL-6 rs1800795 的“C”等位基因与 DN 风险降低相关（C 对 G：P=0.0471）。IL-6 rs1800796 的“G”等位基因与较高的 DN 风险显著相关（GG 对 CC：P=0.0194；GG 对 CC+GC：P=0.0196）。IL-6 rs1800797 的“C”等位基因与 DN 发生率升高相关（C 对 G：P=0.0001；CC 对 GG：P=0.0003；CC 对 GG+CG：P=0.0227；CC+CG 对 GG：P=0.0001），而 IL-6 rs2069837 和 rs2069840 与 DN 易感性无关。
本荟萃分析表明，IL-6 rs1800795、rs1800796 和 rs1800797 对 DN 发生发展具有重要作用，而 IL-6 rs2069837 和 rs2069840 可能与 DN 无关。
