Department of Nephrology and Immunology, Children's Hospital of Hebei Province, Shijiazhuang 050031, China.
Department of Pediatric, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
Biosci Rep. 2020 Oct 30;40(10). doi: 10.1042/BSR20201105.
To evaluate the effects of the single-nucleotide polymorphism (SNP) rs1800795 in interieukin-6 (IL-6) gene on diabetic microvascular complications of Type 2 diabetes mellitus (T2DM), using statistical meta-analysis.
Literature pertaining to the relationship between the SNP rs1800795 and microvascular complications of T2DM including diabetic retinopathy, diabetic nephropathy, diabetic neuropathy and foot disease was retrieved from PubMed, Web of Science Knowledge and SinoMed databases. Original information was analyzed using Stata 12.0, including meta-analysis statistics, test for heterogeneity, evaluation of publication bias and sensitivity. Subgroup analysis was conducted to assess the effect of specific factors on the corresponding results.
In total, 14 eligible articles were obtained. The SNP rs1800795 in IL-6 gene is not correlated with risk of microvascular complications in T2DM. Among the original literature, a genetic model (OR = 1.071, 95% CI: 0.681-1.685, P=0.767), an allelic genetic model (OR = 1.010, 95% CI: 0.959-1.063, P=0.703), a heterozygote genetic model (OR = 1.107, 95% CI: 0.916-1.339, P=0.292), a dominant genetic model (OR = 1.108, 95% CI: 0.885-1.387, P=0.372), and a recessive genetic model (OR = 0.978, 95% CI: 0.646-1.478, P=0.917) were included respectively. In the subgroup analysis by types of diabetic microvascular complications, we found no correlation between the SNP rs1000795 polymorphism and complications of T2DM in either the homozygote genetic model or the allelic genetic model (P<0.05).
Our results demonstrate that rs1800795 polymorphism in IL-6 gene is not correlated with the susceptibility of microvascular complications of T2DM.
通过统计荟萃分析评估白细胞介素 6（IL-6）基因中的单核苷酸多态性（SNP）rs1800795 对 2 型糖尿病（T2DM）患者糖尿病微血管并发症的影响。
从 PubMed、Web of Science 知识数据库和 SinoMed 数据库中检索与 SNP rs1800795 与 T2DM 患者微血管并发症（包括糖尿病视网膜病变、糖尿病肾病、糖尿病神经病变和足部疾病）相关的文献。使用 Stata 12.0 软件分析原始信息，包括荟萃分析统计学、异质性检验、发表偏倚评估和敏感性分析。进行亚组分析以评估特定因素对相应结果的影响。
共纳入 14 项符合条件的文献。IL-6 基因中的 SNP rs1800795 与 T2DM 患者发生微血管并发症的风险无关。在原始文献中，遗传模型（OR=1.071，95%CI：0.681-1.685，P=0.767）、等位基因遗传模型（OR=1.010，95%CI：0.959-1.063，P=0.703）、杂合遗传模型（OR=1.107，95%CI：0.916-1.339，P=0.292）、显性遗传模型（OR=1.108，95%CI：0.885-1.387，P=0.372）和隐性遗传模型（OR=0.978，95%CI：0.646-1.478，P=0.917）。在按糖尿病微血管并发症类型进行的亚组分析中，我们发现 SNP rs1000795 多态性与 T2DM 患者的任何一种并发症在同合子遗传模型或等位基因遗传模型中均无相关性（P<0.05）。
我们的结果表明，IL-6 基因中的 rs1800795 多态性与 T2DM 患者微血管并发症的易感性无关。
