Cui Bo, Feng Lei, Wang Chunxin, Yang Dongsheng, Yu Manli, Zeng Zhanghua, Wang Yan, Sun Changjiao, Zhao Xiang, Cui Haixin
Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.
PLoS One. 2016 Aug 8;11(8):e0160877. doi: 10.1371/journal.pone.0160877. eCollection 2016.
Poorly water-soluble compounds are difficult to develop as pesticide products and face great challenges in water-based and environmentally friendly formulation development. In this study, high pressure homogenization combined with lyophilization was adopted to prepare the solid nanodispersions of chlorantraniliprole with poor solubility and high melting point. The mean particle sizes of the solid nanodispersions with different pesticide contents were all less than 75 nm, even when the content was up to 91.5%. For the 2.5% chlorantraniliprole solid nanodispersion with the mean particle size of 29 nm, the suspensibility and wetting time in water were 97.32% and 13 s, respectively. The re-dispersibility and wettability were superior to those of conventional water dispersible granules. The retention on the rice leaf of 18.7 mg/cm2 was 1.5 and 3 times that of commercial aqueous suspension concentrate and pure water. The bioassay result to diamondback moths indicated that the toxicity of the solid nanodispersion was 3.3 and 2.8 times that of technical and aqueous suspension concentrate, respectively. Moreover, the solid nanodispersion has the advantages of total avoidance of organic solvents, significant reduction of surfactants and feasibility of obtaining high concentration nanoformulations. The solid nanodispersion is an attractive candidate for improving pesticide solubility and efficacy, and its application in crop production will reduce both residues in food and environmental pollution of pesticide.
水溶性差的化合物难以开发成农药产品,在水基和环境友好型制剂开发方面面临巨大挑战。本研究采用高压均质结合冻干法制备了溶解度低、熔点高的氯虫苯甲酰胺固体纳米分散体。不同农药含量的固体纳米分散体的平均粒径均小于75nm,即使含量高达91.5%时也是如此。对于平均粒径为29nm的2.5%氯虫苯甲酰胺固体纳米分散体,其在水中的悬浮率和润湿时间分别为97.32%和13s。其再分散性和润湿性优于传统水分散粒剂。在水稻叶片上的持留量为18.7mg/cm2,分别是市售水悬浮剂和纯水的1.5倍和3倍。对小菜蛾的生物测定结果表明,固体纳米分散体的毒性分别是原药和水悬浮剂的3.3倍和2.8倍。此外,固体纳米分散体具有完全避免使用有机溶剂、显著减少表面活性剂用量以及能够获得高浓度纳米制剂的优点。固体纳米分散体是提高农药溶解度和药效的一个有吸引力的选择,其在作物生产中的应用将减少食品中的农药残留和环境污染。