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氯虫苯甲酰胺高载药量和控释微胶囊制剂的研制。

Development of a Chlorantraniliprole Microcapsule Formulation with a High Loading Content and Controlled-Release Property.

机构信息

Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics & Chemistry, Institute of Chemistry , Chinese Academy of Sciences , Beijing 100190 , China.

University of Chinese Academy of Sciences , Beijing 100049 , China.

出版信息

J Agric Food Chem. 2018 Jul 5;66(26):6561-6568. doi: 10.1021/acs.jafc.7b01295. Epub 2017 May 10.

Abstract

Microcapsule formulations have been widely developed and used in agriculture to improve pesticide utilization and reduce environmental pollution. However, commercial formulations of chlorantraniliprole (CAP) are only traditional formulations due to poor solubility of CAP in organic solvents. Here, adopting a solid in oil in water (S/O/W) double-emulsion method combined with premix membrane emulsion, we successfully constructed CAP microcapsule formulations with a high loading content. The microcapsule formulations with good light and thermal stability showed a significantly sustained release for a long period, which could be optimally regulated by tuning the surface porosity and size of the porous microcapsules. Bioassay studies showed that control efficacy of the porous microcapsule formulations against Plutella xylostella was superior to that of the commercial formulation. These results demonstrated that such a porous microcapsule delivery system should have great potential for further exploration as a commercial CAP formulation.

摘要

微胶囊制剂在农业中得到了广泛的开发和应用,以提高农药利用率并减少环境污染。然而,由于氯虫苯甲酰胺(CAP)在有机溶剂中的溶解度较差,商业制剂仍为传统制剂。在这里,我们采用固-油-水(S/O/W)双乳液法结合预混膜乳液,成功构建了具有高载药量的 CAP 微胶囊制剂。具有良好光热稳定性的微胶囊制剂表现出明显的长期缓释效果,通过调节多孔微胶囊的表面孔隙率和尺寸可以对其进行最佳调控。生物测定研究表明,多孔微胶囊制剂对小菜蛾的防治效果优于商业制剂。这些结果表明,这种多孔微胶囊递药系统作为一种商业 CAP 制剂具有很大的探索潜力。

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