Cui Bo, Wang Chunxin, Zhao Xiang, Yao Junwei, Zeng Zhanghua, Wang Yan, Sun Changjiao, Liu Guoqiang, Cui Haixin
Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.
PLoS One. 2018 Jan 23;13(1):e0191742. doi: 10.1371/journal.pone.0191742. eCollection 2018.
Poorly water-soluble and photosensitive pesticide compounds are difficult to formulate as solvent-free nanoformulations with high efficacy. A avermectin solid nanodispersion with a mean particle size of 188 nm was developed by microprecipitation and lyophilisation techniques. The suspensibility and wetting time of the solid nanodispersion in water were 99.8% and 13 s, respectively, superior to those of conventional water dispersible granules and wettable powders. The anti-photolysis performance of the nanoformulation was twice that of the technical material, and the biological activity against diamondback moths was more than 1.5 times that of the conventional solid formulations while taking LC 50 as the evaluation index. Moreover, the formulation composition substantially decreased the surfactant content and avoided organic solvents. Microprecipitation combined with lyophilisation is an easy and promising method to construct solid nanoformulations for pesticides with poor water solubility and environmental sensitivity. The application of the highly effective solid nanodispersion in crop production will have a great potential in reducing chemical residues and environmental pollution.
水溶性差且对光敏感的农药化合物难以配制成高效的无溶剂纳米制剂。通过微沉淀和冻干技术制备了平均粒径为188 nm的阿维菌素固体纳米分散体。该固体纳米分散体在水中的悬浮率和润湿时间分别为99.8%和13 s，优于传统的水分散粒剂和可湿性粉剂。该纳米制剂的抗光解性能是原药的两倍，以LC50为评价指标，其对小菜蛾的生物活性是传统固体剂型的1.5倍以上。此外，该制剂配方大幅降低了表面活性剂含量并避免了使用有机溶剂。微沉淀结合冻干是一种简便且有前景的方法，可用于构建针对水溶性差且对环境敏感的农药的固体纳米制剂。这种高效固体纳米分散体在作物生产中的应用在减少化学残留和环境污染方面具有巨大潜力。
