Peplonska Beata, Bukowska Agnieszka, Lie Jenny Anne, Gromadzinska Jolanta, Zienolddiny Shanbeh
Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, 8, Teresy St, 91-348 Lodz, Poland.
Scand J Work Environ Health. 2016 Sep 1;42(5):435-46. doi: 10.5271/sjweh.3581. Epub 2016 Aug 8.
The aims of our study were to (i) investigate the association between rotating night shift work and blood concentrations of estradiol, testosterone and dehydroepiandrosterone sulfate (DHEAS) and (2) evaluate the role of their non-occupational determinants.
A cross-sectional study was conducted on 345 premenopausal and 187 postmenopausal nurses and midwives (263 women working rotating night shifts and 269 women working during days). Data from in-person interviews were used, anthropometric measurements were performed, and body mass index (BMI) and waist- to-hip ratio were calculated. Morning blood and spot urine samples were collected. Multiple linear regression models were fitted with hormone concentrations as dependent variables, and night shift work characteristics and demographic, reproductive, lifestyle and anthropometric determinants as independent variables. Modification of the effect by chronotype was examined.
Among postmenopausal women, we observed a statistically significant positive association between the total duration of night shift work >15 years and estradiol level (P<0.05 when compared to night work duration <5 years). Night shift work characteristics were significantly associated with estradiol among morning-type postmenopausal women. The well-established associations between hormones and their major determinants, such as age and BMI, were confirmed.
The findings of our study imply that prolonged night shift work may be associated with increased estradiol levels among postmenopausal women, especially among the morning-type postmenopausal women.
我们研究的目的是（i）调查轮班制夜班工作与雌二醇、睾酮和硫酸脱氢表雄酮（DHEAS）血药浓度之间的关联，以及（2）评估其非职业性决定因素的作用。
对345名绝经前护士和助产士以及187名绝经后护士和助产士进行了一项横断面研究（263名女性从事轮班制夜班工作，269名女性从事日间工作）。使用了面对面访谈的数据，进行了人体测量，并计算了体重指数（BMI）和腰臀比。采集了早晨血液和随机尿样。以激素浓度为因变量，以夜班工作特征以及人口统计学、生殖、生活方式和人体测量学决定因素为自变量，拟合多元线性回归模型。研究了昼夜节律类型对这种效应的影响。
在绝经后女性中，我们观察到夜班工作总时长>15年与雌二醇水平之间存在统计学上显著的正相关（与夜班工作时长<5年相比，P<0.05）。在早晨型绝经后女性中，夜班工作特征与雌二醇显著相关。激素与其主要决定因素（如年龄和BMI）之间已确定的关联得到了证实。
我们的研究结果表明，长期夜班工作可能与绝经后女性雌二醇水平升高有关，尤其是在早晨型绝经后女性中。
