Xiao Yunfei, Yin Shan, Cui Jianwei, Bai Yunjin, Yang Zhenzhen, Wang Jiahao, Wang Jia
Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Front Nutr. 2023 May 9;10:1137668. doi: 10.3389/fnut.2023.1137668. eCollection 2023.
The objective of this study is to explore the association between the prevalence rates of circadian syndrome (CircS) and testosterone deficiency (TD).
Cross-sectional analysis was conducted on the basis of the National Health and Nutrition Examination Survey 2011-2016. The target population was males aged ≥20 years old. A total of three multivariable logistic regression models were built to elucidate the association between the prevalence rates of CircS and TD. Interactive and stratified analyses were employed to explore whether some variables can modify the above association. Sensitivity analyses were also conducted to verify the stability of the results with extreme values removed.
A total of 3,436 eligible participants were involved. Multivariable logistic regression in the fully adjusted model suggested the CircS group had a significantly higher prevalence rate of TD compared with the non-CircS group (OR = 2.284, 95%CI 1.569 to 3.323). No significant correlation between the number of CircS components and TD was observed in any of the three models. The interactive and stratified analyses showed the association was more obvious in the population with moderate or vigorous activities. The results were robust after extreme data were excluded.
There is a positive association between the prevalence rates of CircS and TD in US men. The association becomes more obvious owing to moderate or vigorous activities.
本研究旨在探讨昼夜节律综合征（CircS）患病率与睾酮缺乏（TD）之间的关联。
基于2011 - 2016年美国国家健康与营养检查调查进行横断面分析。目标人群为年龄≥20岁的男性。共建立了三个多变量逻辑回归模型，以阐明CircS患病率与TD之间的关联。采用交互分析和分层分析来探讨某些变量是否会改变上述关联。还进行了敏感性分析，以验证去除极端值后结果的稳定性。
共有3436名符合条件的参与者。完全调整模型中的多变量逻辑回归表明，与非CircS组相比，CircS组的TD患病率显著更高（OR = 2.284，95%CI为1.569至3.323）。在三个模型中的任何一个中，均未观察到CircS成分数量与TD之间存在显著相关性。交互分析和分层分析表明，在进行中度或剧烈活动的人群中，这种关联更为明显。排除极端数据后，结果仍然稳健。
在美国男性中，CircS患病率与TD之间存在正相关。由于中度或剧烈活动，这种关联更为明显。
