Einarsson Elin, Ma'ayeh Showgy, Svärd Staffan G
Department of Cell and Molecular Biology, BMC, Box 596, Uppsala University, SE-751 24 Uppsala, Sweden.
Department of Cell and Molecular Biology, BMC, Box 596, Uppsala University, SE-751 24 Uppsala, Sweden.
Curr Opin Microbiol. 2016 Dec;34:47-52. doi: 10.1016/j.mib.2016.07.019. Epub 2016 Aug 6.
Giardia intestinalis is a non-invasive protozoan parasite infecting the upper small intestine causing acute, watery diarrhea or giardiasis in 280 million people annually. Asymptomatic infections are equally common and recent data have suggested that infections even can be protective against other diarrheal diseases. Most symptomatic infections resolve spontaneously but infections can lead to chronic disease and treatment failures are becoming more common world-wide. Giardia infections can also result in irritable bowel syndrome (IBS) and food allergies after resolution. Until recently not much was known about the mechanism of giardiasis or the cause of post-giardiasis syndromes and treatment failures, but here we will describe the recent progress in these areas.
肠道贾第虫是一种非侵袭性原生动物寄生虫，感染小肠上段，每年导致2.8亿人出现急性水样腹泻或贾第虫病。无症状感染同样常见，最近的数据表明，感染甚至可能对其他腹泻疾病有保护作用。大多数有症状的感染会自行缓解，但感染可能导致慢性病，而且治疗失败在全球范围内越来越普遍。贾第虫感染在痊愈后还可能导致肠易激综合征（IBS）和食物过敏。直到最近，人们对贾第虫病的发病机制、贾第虫病后综合征的病因以及治疗失败的原因了解甚少，但在此我们将描述这些领域的最新进展。
