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急诊腹部手术后的发病率和死亡率:对4346例计划进行急诊剖腹手术或腹腔镜检查的患者的分析。

Morbidity and mortality rates after emergency abdominal surgery: an analysis of 4346 patients scheduled for emergency laparotomy or laparoscopy.

作者信息

Tolstrup Mai-Britt, Watt Sara Kehlet, Gögenur Ismail

机构信息

Department of Gastrointestinal Surgery, Copenhagen University Hospital, Herlev, Herlev, Denmark.

Department Surgery, Center for Surgical Science, Zealand University Hospital, Copenhagen University, Koege, Denmark.

出版信息

Langenbecks Arch Surg. 2017 Jun;402(4):615-623. doi: 10.1007/s00423-016-1493-1. Epub 2016 Aug 9.

Abstract

PURPOSE

Emergency abdominal surgery results in a high rate of post-operative complications and death. There are limited data describing the emergency surgical population in details. We aimed to give a detailed analyses of complications and mortality in a consecutive group of patients undergoing acute abdominal surgery over a 4-year period.

METHODS

This observational study was conducted between 2009 and 2013 at Copenhagen University Hospital Herlev, Denmark. All patients scheduled for emergency laparotomy or laparoscopy were included. Pre-, intra-, and post-operative data were collected from medical records. Complications were registered according to the Clavien-Dindo classification. Cox regression analysis was performed to identify risk factors for mortality.

RESULTS

A total of 4,346 patients underwent emergency surgery, of whom 14 % had surgical complications and 23 % medical complications. The overall 30-day mortality was 8 % with 50 % of those in this group over 80 years of age. The 30-day mortality rates were 0.8 % (95 % CI 0.5-1.1) and 17 % (95 % CI 15.5-18.9), respectively, for the laparoscopy and the laparotomy groups. The overall death rate within 24 h of surgery was 21 %. Several risk factors for 30- and 90-day mortality were identified: age, ASA ≥3 (American Society of Anaesthesiologists physical status classification), performance score (Zubroed/WHOclassification), cirrhosis of the liver, chronic nephropathy, several medical conditions, and malignancy.

CONCLUSION

Almost one in five patients died after emergency laparotomy, of whom one in five died within 24 h of surgery. Predictors for poor outcome were identified.

摘要

目的

急诊腹部手术术后并发症发生率和死亡率较高。详细描述急诊手术人群的数据有限。我们旨在对连续4年接受急性腹部手术的一组患者的并发症和死亡率进行详细分析。

方法

这项观察性研究于2009年至2013年在丹麦哥本哈根大学医院赫勒夫进行。纳入所有计划进行急诊剖腹手术或腹腔镜手术的患者。从病历中收集术前、术中和术后数据。根据Clavien-Dindo分类法记录并发症。进行Cox回归分析以确定死亡的危险因素。

结果

共有4346例患者接受了急诊手术,其中14%发生手术并发症,23%发生内科并发症。总体30天死亡率为8%,该组中50%的患者年龄超过80岁。腹腔镜手术组和剖腹手术组的30天死亡率分别为0.8%(95%CI 0.5-1.1)和17%(95%CI 15.5-18.9)。手术24小时内的总体死亡率为21%。确定了30天和90天死亡率的几个危险因素:年龄、美国麻醉医师协会身体状况分类(ASA)≥3、性能评分(Zubroed/WHO分类)、肝硬化、慢性肾病、多种内科疾病和恶性肿瘤。

结论

急诊剖腹手术后几乎五分之一的患者死亡,其中五分之一在手术24小时内死亡。确定了预后不良的预测因素。

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