脑脊液中β淀粉样蛋白浓度低与女性较差的延迟记忆回忆能力相关。

Low Cerebrospinal Fluid Amyloid-Beta Concentration Is Associated with Poorer Delayed Memory Recall in Women.

作者信息

Haapalinna Fanni, Paajanen Teemu, Penttinen Janne, Kokki Hannu, Kokki Merja, Koivisto Anne M, Hartikainen Päivi, Solje Eino, Hänninen Tuomo, Remes Anne Marja, Herukka Sanna-Kaisa

机构信息

Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Finland.

Finnish Institute of Occupational Health, Mental Health and Cognition Team, Helsinki, Finland.

出版信息

Dement Geriatr Cogn Dis Extra. 2016 Jul 19;6(2):303-12. doi: 10.1159/000446425. eCollection 2016 May-Aug.

DOI:10.1159/000446425

PMID:27504119

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4965537/

Abstract

BACKGROUND

Data on the association of memory performance with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are inconsistent. The Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery (CERAD-NB) is a commonly used validated cognitive tool; however, only few studies have examined its relationship with CSF biomarkers for AD. We studied the correlation of pathological changes in CSF biomarkers with various CERAD-NB subtests and total scores.

METHODS

Out of 79 subjects (36 men, mean age 70.5 years), 63 had undergone an assessment of cognitive status with CERAD-NB and a CSF biomarker analysis due to a suspected memory disorder, and 16 were controls with no memory complaint.

RESULTS

In women we found a significant correlation between CSF amyloid-beta (Aβ1-42) and several subtests measuring delayed recall. Word List Recall correlated with all markers: Aβ1-42 (r = 0.323, p = 0.035), tau (r = -0.304, p = 0.050) and hyperphosphorylated tau (r = -0.331, p = 0.046). No such correlations were found in men.

CONCLUSIONS

CSF biomarkers correlate with delayed memory scores in CERAD-NB in women, and women may have more actual AD pathology at the time of the investigations than men.

摘要

背景

关于记忆表现与阿尔茨海默病（AD）脑脊液（CSF）生物标志物之间关联的数据并不一致。建立阿尔茨海默病神经心理成套测验登记处（CERAD-NB）是一种常用的经过验证的认知工具；然而，只有少数研究探讨了其与AD脑脊液生物标志物的关系。我们研究了脑脊液生物标志物的病理变化与各种CERAD-NB子测验及总分之间的相关性。

方法

在79名受试者（36名男性，平均年龄70.5岁）中，63名因疑似记忆障碍接受了CERAD-NB认知状态评估和脑脊液生物标志物分析，16名是无记忆主诉的对照者。

结果

在女性中，我们发现脑脊液淀粉样蛋白β（Aβ1-42）与几个测量延迟回忆的子测验之间存在显著相关性。单词表回忆与所有标志物相关：Aβ1-42（r = 0.323，p = 0.035）、tau（r = -0.304，p = 0.050）和磷酸化tau（r = -0.331，p = 0.046）。在男性中未发现此类相关性。