Hestad Knut Asbjorn, Horndalsveen Peter Otto, Engedal Knut
Department of Health and Nursing Science, Faculty of Social and Health Sciences, Inland Norway University of Applied Sciences, Elverum, Norway.
Department of Research, Innlandet Hospital Trust, Ottestad, Norway.
Front Aging Neurosci. 2021 Oct 28;13:652510. doi: 10.3389/fnagi.2021.652510. eCollection 2021.
: The aim of the study was to determine if systolic blood pressure (SBP), total-tau (t-tau), and beta-amyloid (Aβ) in the cerebral spinal fluid (CSF) were associated with the results on the Consortium to Establish a Registry for Alzheimer's Disease Word List (CERAD-WL) immediate and delayed recall, and the Mini Mental State Examination (MMSE) in "younger" older adults, controlling for age and sex. : We included 72 participants, mean age: 62.9 (SD 8.6, range 41-76) from a Norwegian memory clinic; eight were diagnosed with subjective cognitive decline, 32 with mild cognitive impairment (MCI), 30 with dementia of the Alzheimer's type (DAT), and two with combined DAT and vascular dementia (VaD). Data were examined in three fitted multiple linear regression models using the CERAD-WL immediate and delayed recall, and MMSE as dependent variables; and SBP, t-tau, and Aβ as independent variables, controlling for age and sex. : The strongest associations were found in the model using CERAD-WL delayed recall as the dependent variable, where 45% of the variance was explained (standardized Beta = -0.313, = 0.004 for t-tau and standardized Beta -0.238, = 0.01 for SBP). The unique contribution of age was close to 8%, t-tau close to 7%, and SBP above 5%. When cardiovascular medication was entered into the analysis, the explained variance increased to 51% and Aβ became significant (standardized Beta = 0.216, = 0.03). Participants on this medication exhibited worse performance on CERAD-WL delayed recall than those who were not on medication. Age (7%), t-tau (6%), and SBP (5%) showed the same unique contribution, whereas medication contributed 6% and Aβ contributed 4%. CERAD-WL immediate recall, and MMSE yielded similar findings, but explained variance was poorer for these two variables. : Both elevated SBP and t-tau were associated with poorer cognitive performance, especially delayed recall. Those on cardiovascular medication were more impaired than were participants who were not on this medication-a finding that probably reflected cerebral incidents in the medicated group.
本研究的目的是确定收缩压（SBP）、脑脊液（CSF）中的总tau蛋白（t-tau）和β-淀粉样蛋白（Aβ）是否与阿尔茨海默病词汇表注册联盟（CERAD-WL）即时和延迟回忆结果以及“年轻”老年人的简易精神状态检查表（MMSE）相关，并对年龄和性别进行控制。我们纳入了来自挪威记忆诊所的72名参与者，平均年龄为62.9岁（标准差8.6，范围41 - 76岁）；其中8人被诊断为主观认知下降，32人患有轻度认知障碍（MCI），30人患有阿尔茨海默病型痴呆（DAT），2人患有DAT合并血管性痴呆（VaD）。使用CERAD-WL即时和延迟回忆以及MMSE作为因变量，SBP、t-tau和Aβ作为自变量，在三个拟合的多元线性回归模型中对数据进行检验，并对年龄和性别进行控制。在以CERAD-WL延迟回忆作为因变量的模型中发现了最强的关联，其中45%的方差得到了解释（t-tau的标准化β = -0.313，P = 0.004；SBP的标准化β = -0.238，P = 0.01）。年龄的独特贡献接近8%，t-tau接近7%，SBP超过5%。当将心血管药物纳入分析时，解释的方差增加到51%，Aβ变得显著（标准化β = 0.216，P = 0.03）。服用这种药物的参与者在CERAD-WL延迟回忆方面的表现比未服用药物的参与者更差。年龄（7%）、t-tau（6%）和SBP（5%）显示出相同的独特贡献，而药物贡献了6%，Aβ贡献了4%。CERAD-WL即时回忆和MMSE得出了类似的结果，但这两个变量的解释方差较差。收缩压升高和t-tau升高均与较差的认知表现相关，尤其是延迟回忆。服用心血管药物的参与者比未服用该药物的参与者受损更严重——这一发现可能反映了用药组的脑部事件。
