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S100从生理到病理的确定性

Certainty of S100 from Physiology to Pathology.

作者信息

Kuberappa Puneeth Horatti, Bagalad Bhavana Shivanand, Ananthaneni Anuradha, Kiresur Md Asif, Srinivas Guduru Vijay

机构信息

Senior Lecturer, Department of Oral Pathology and Microbiology, St Joseph Dental College , Eluru, Andhra Pradesh, India .

Professor, Department of Oral Pathology and Microbiology, St Joseph Dental College , Eluru, Andhra Pradesh, India .

出版信息

J Clin Diagn Res. 2016 Jun;10(6):ZE10-5. doi: 10.7860/JCDR/2016/17949.8022. Epub 2016 Jun 1.

DOI:10.7860/JCDR/2016/17949.8022
PMID:27504432
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4963792/
Abstract

S100 exists in wide variety of tissues and cell types, originally isolated from brain tissue and they are of low molecular weight proteins. S100 is evenly distributed in cytoplasm and also in nucleoplasm and is involved in both intercellular and extracellular functions. S100 protein is generally expressed in normal and also in pathological conditions. In current review, we discuss: a) update nomenclature of the various S100 proteins, b) expression of S100 in oral diseases (different soft tissue tumors, odontogenic cyst and tumor) for diagnostic value and also to know their histogenesis, c) role of S100 and RAGE receptor in oral squamous cell carcinoma.

摘要

S100存在于多种组织和细胞类型中，最初是从脑组织中分离出来的，它们是低分子量蛋白质。S100均匀分布于细胞质以及核质中，参与细胞间和细胞外功能。S100蛋白通常在正常和病理条件下均有表达。在本综述中，我们讨论：a）各种S100蛋白的更新命名法，b）S100在口腔疾病（不同软组织肿瘤、牙源性囊肿和肿瘤）中的表达，以用于诊断价值并了解其组织发生，c）S100和RAGE受体在口腔鳞状细胞癌中的作用。

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