Lee Na-Young, Oh Jeong-Seop, Kim Dae-Yong, Im Tae-Kyun, Kim Dae Young
Laboratory of Veterinary Pathology and Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
CHOO-CHOO Animal Hospital, Seoul, Republic of Korea.
J Vet Diagn Invest. 2025 Mar;37(2):380-384. doi: 10.1177/10406387251316831. Epub 2025 Feb 2.
Neuroglial choristomas are rare in humans and animals. During a routine medical examination, an ovarian mass was found in a 5-y-old female mixed-breed dog. Histologically, the ovarian mass was well-defined, expansile, and composed of large polygonal cells resembling well-differentiated neurons and scattered smaller cells resembling glial cells. Immunohistochemically, the neuron-like cells were positive for neuronal nuclei; the smaller cells were positive for glial fibrillar acidic protein, oligodendrocyte transcription factor 2, and ionized calcium-binding adaptor protein-1. Ovarian neuroglial choristoma was diagnosed.
神经胶质迷离瘤在人类和动物中都很罕见。在一次常规体检中,一只5岁的雌性混种犬被发现卵巢有肿物。组织学检查显示,该卵巢肿物边界清晰,呈膨胀性生长,由类似分化良好的神经元的大的多边形细胞和散在的类似神经胶质细胞的较小细胞组成。免疫组织化学检查显示,神经元样细胞神经元核呈阳性;较小的细胞胶质纤维酸性蛋白、少突胶质细胞转录因子2和离子钙结合衔接蛋白-1呈阳性。诊断为卵巢神经胶质迷离瘤。