Braga Vania
Molecular Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, SW7 2AZ London, UK.
Curr Opin Cell Biol. 2016 Oct;42:138-145. doi: 10.1016/j.ceb.2016.07.006. Epub 2016 Aug 6.
The characteristic tall and elongated shape of epithelial cells requires specialized adhesive structures and a distinct organization of cytoskeletal filaments. Cytoskeletal networks coordinate a precise organization of adhesive and signalling complexes along cell-cell contacts and enable exquisite strong cohesion among epithelial cells. E-cadherin, a calcium-dependent adhesion receptor, is an essential adhesive system in epithelia and its dynamic regulation and pathways that stabilize cell-cell adhesion have been extensively studied. This review highlights the less understood mechanisms underlying how cadherin receptor signalling drives cytoskeletal rearrangements which ultimately define the epithelial cell shape. In the past two years, new insights identify specific actin-binding proteins and regulators of the epithelial cytoskeleton as a framework to support junction dynamics, plasticity and maintenance.
上皮细胞特有的高且细长的形状需要特殊的粘附结构和细胞骨架丝的独特组织。细胞骨架网络沿着细胞 - 细胞接触协调粘附和信号复合物的精确组织，并使上皮细胞之间具有极强的凝聚力。E - 钙粘蛋白是一种钙依赖性粘附受体，是上皮细胞中必不可少的粘附系统，其动态调节以及稳定细胞 - 细胞粘附的途径已得到广泛研究。本综述重点介绍了钙粘蛋白受体信号传导如何驱动细胞骨架重排的鲜为人知的机制，而这种重排最终决定了上皮细胞的形状。在过去两年中，新的见解确定了特定的肌动蛋白结合蛋白和上皮细胞骨架的调节因子，作为支持连接动态、可塑性和维持的框架。
