Xing Jianxiao, Wang Ying, Peng Aihong, Li Junqin, Niu Xuping, Zhang Kaiming
ShanXi Key Laboratory of Stem Cells for Immunological Dermatosis, State Key Breeding Laboratory of Stem Cells for Immunological Dermatosis, Taiyuan Central Hospital, Dong San Dao Xiang, Taiyuan, China.
Front Mol Biosci. 2024 Jul 24;11:1408287. doi: 10.3389/fmolb.2024.1408287. eCollection 2024.
Actin remodeling proteins are important in immune diseases and regulate cell cytoskeletal responses. These responses play a pivotal role in maintaining the delicate balance of biological events, protecting against acute or chronic inflammation in a range of diseases. Cofilin (CFL) and actin depolymerization factor (ADF) are potent actin-binding proteins that cut and depolymerize actin filaments to generate actin cytoskeleton dynamics. Although the molecular mechanism by which actin induces actin cytoskeletal reconstitution has been studied for decades, the regulation of actin in the inflammatory process has only recently become apparent. In this paper, the functions of the actin cytoskeleton and ADF/cofilin superfamily members are briefly introduced, and then focus on the role of CFL1 in inflammatory response.
肌动蛋白重塑蛋白在免疫疾病中很重要，并调节细胞细胞骨架反应。这些反应在维持生物事件的微妙平衡、预防一系列疾病中的急性或慢性炎症方面发挥着关键作用。丝切蛋白（CFL）和肌动蛋白解聚因子（ADF）是强效的肌动蛋白结合蛋白，它们切割并解聚肌动蛋白丝以产生肌动蛋白细胞骨架动态变化。尽管几十年来一直在研究肌动蛋白诱导肌动蛋白细胞骨架重构的分子机制，但肌动蛋白在炎症过程中的调节作用直到最近才变得明显。本文简要介绍了肌动蛋白细胞骨架和ADF/丝切蛋白超家族成员的功能，然后重点阐述CFL1在炎症反应中的作用。
