Jørgensen Mette Rose, Castiblanco Gina, Twetman Svante, Keller Mette Kirstine
Am J Dent. 2016 Jun;29(3):127-31.
This review summarized the available literature on the prevention of childhood caries through biofilm engineering with probiotic bacteria in early childhood.
Three databases (PubMed, Cochrane Library and Trip) were searched through January, 2016 for randomized controlled trials published in English. Out of 144 abstracts, seven studies fulfilled the predetermined inclusion criteria and were quality assessed with respect to risk of bias independently by two examiners. Due to the paucity and heterogeneity, a narrative synthesis was performed. The effect size was estimated from the caries prevalence and expressed as prevented fraction and number needed to treat.
Probiotic supplements were better than placebo in preventing early childhood caries in all seven studies although the difference was statistically significant in only four of them. The prevented fraction ranged from 11% to 61% with a median of 48%. However, the quality of the evidence was low or very low and further translational research is needed to investigate this preventive approach in the clinic.
本综述总结了关于幼儿期通过益生菌生物膜工程预防儿童龋齿的现有文献。
检索了三个数据库（PubMed、Cochrane图书馆和Trip），截至2016年1月，查找以英文发表的随机对照试验。在144篇摘要中，七项研究符合预定的纳入标准，并由两名审查员独立对偏倚风险进行质量评估。由于研究数量不足且存在异质性，因此进行了叙述性综合分析。根据龋齿患病率估计效应大小，并表示为预防率和需治疗人数。
在所有七项研究中，益生菌补充剂在预防幼儿龋齿方面均优于安慰剂，尽管其中只有四项研究的差异具有统计学意义。预防率在11%至61%之间，中位数为48%。然而，证据质量低或非常低，需要进一步的转化研究以在临床中研究这种预防方法。
