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一种新型三肽水凝胶剂的合成、表征及体外生物相容性评估，作为组织工程应用的一种有前景的支架材料。

Synthesis, characterization and in vitro biocompatibility assessment of a novel tripeptide hydrogelator, as a promising scaffold for tissue engineering applications.

作者信息

Pospišil Tihomir, Ferhatović Hamzić Lejla, Brkić Ahmed Lada, Lovrić Marija, Gajović Srećko, Frkanec Leo

机构信息

Laboratory for Supramolecular Chemistry, Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb, Croatia.

出版信息

Biomater Sci. 2016 Oct 20;4(10):1412-6. doi: 10.1039/c6bm00287k. Epub 2016 Aug 10.

DOI:10.1039/c6bm00287k
PMID:27508285
Abstract

We have synthesized and characterized a self-assembling tripeptide hydrogelator Ac-l-Phe-l-Phe-l-Ala-NH2. A series of experiments showed that the hydrogel material could serve as a stabile and biocompatible physical support as it improves the survival of HEK293T cells in vitro, thus being a promising biomaterial for use in tissue engineering applications.

摘要

我们合成并表征了一种自组装三肽水凝胶剂Ac-l-苯丙氨酸-l-苯丙氨酸-l-丙氨酸-NH2。一系列实验表明，这种水凝胶材料可以作为一种稳定且生物相容的物理支架，因为它能提高HEK293T细胞在体外的存活率，因此是一种有前景的用于组织工程应用的生物材料。

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