Yan Yansheng, Wu Shouli, Chen Liang, Yan Pingping, Qiu Yuefeng, Xie Meirong, Wang Zhenghua, Lin Xun
Fujian Provincial Center for Disease Control and Prevention, No. 76 Jintai Road, Fuzhou 350001, China.
Fujian Provincial Key Laboratory of Zoonosis Research, No. 76 Jintai Road, Fuzhou 350001, China.
Int J Environ Res Public Health. 2016 Aug 6;13(8):794. doi: 10.3390/ijerph13080794.
The aim of this study was to investigate the shift in the epidemiological features of HIV/AIDS during the last three decades in Fujian Province, southeastern China, so as to provide evidence for the development of novel HIV/AIDS control strategies.
Data pertaining to the conventional surveillance, sentinel surveillance and epidemiological survey in Fujian Province during the period from 1987 to 2015 were collected. The epidemiological trends were described, and the subtypes of HIV strain were genotyped. In addition, the response to antiretroviral therapy was evaluated, and HIV genotypic resistance was assayed.
There was an increasing trend observed in the reported cases of HIV/AIDS in Fujian Province. From 1987 to the end of 2015, a total of 8651 HIV/AIDS cases were reported across the province, with totally 1557 deaths found. Among the total cases, the ratio of male/female cases was 3.7:1, which appeared to be an increasing trend; 77.1% cases were detected in young and middle-aged populations aged 19 to 50 years, however, the new HIV infections recently tended to occur in young people aged 15 to 18 years and in populations aged 50 years and older. Among all infected individuals, 49.3% were married, however, the percentage of unmarried cases increased from 6.67% before 1994 to 40.1% in 2015; 64.8% had junior high school education or lower, however, the proportion of HIV/AIDS cases with junior college education or above gradually increased from 6.5% in 2009 to 21.4% in 2015. The reported HIV/AIDS cases were predominantly found in coastal regions; however, a rapidly increasing trend was seen in the number of HIV/AIDS cases in inland regions, and the geographical variation of the cases gradually reduced. There were multiple routes of HIV transmission found in Fujian Province, and 94.2% infections were sexually transmitted, with a large increase in the percentage of male homosexual transmission. A variety of HIV-1 subtypes were genotyped in the province during the study period, and CRF01-AE and CRF07-BC intersubtype recombinant forms were predominant; however, a declining trend in the proportion of HIV-1 CRF01-AE recombinant virus and a significant rise in the proportion of HIV-1 CRF07-BC recombinant virus were observed. Over 90% HIV inhibition was found in all cases receiving antiretroviral therapy during the period from 2011 to 2015, indicating a low prevalence of HIV drug resistance.
An increasing trend is still observed in the HIV/AIDS epidemics in Fujian Province, southeastern China. However, the epidemiological pattern of HIV/AIDS has recently changed in the province, and effective control interventions targeting the shift in the epidemiological features of HIV/AIDS should therefore be implemented to control the spread of the epidemic.
本研究旨在调查中国东南部福建省过去三十年中艾滋病毒/艾滋病流行病学特征的变化，为制定新的艾滋病毒/艾滋病控制策略提供依据。
收集福建省1987年至2015年期间常规监测、哨点监测和流行病学调查的数据。描述流行病学趋势，并对艾滋病毒毒株亚型进行基因分型。此外，评估抗逆转录病毒治疗的反应，并检测艾滋病毒基因型耐药性。
福建省报告的艾滋病毒/艾滋病病例呈上升趋势。从1987年到2015年底，全省共报告8651例艾滋病毒/艾滋病病例，共发现1557例死亡。在所有病例中，男女病例比例为3.7:1，呈上升趋势；77.1%的病例在19至50岁的中青年人群中被检测到，然而，最近新的艾滋病毒感染倾向于发生在15至18岁的年轻人和50岁及以上的人群中。在所有感染者中，49.3%已婚，然而，未婚病例的比例从1994年前的6.67%增加到2015年的40.1%；64.8%的人初中及以下文化程度，然而，大专及以上文化程度的艾滋病毒/艾滋病病例比例从2009年的6.5%逐渐增加到2015年的21.4%。报告的艾滋病毒/艾滋病病例主要集中在沿海地区；然而，内陆地区艾滋病毒/艾滋病病例数量呈快速上升趋势，病例的地理差异逐渐缩小。福建省发现了多种艾滋病毒传播途径，94.2%的感染是性传播，男性同性恋传播的比例大幅增加。在研究期间，该省对多种艾滋病毒-1亚型进行了基因分型，CRF01-AE和CRF07-BC亚型重组形式占主导；然而，观察到艾滋病毒-1 CRF01-AE重组病毒的比例呈下降趋势，艾滋病毒-1 CRF07-BC重组病毒的比例显著上升。2011年至2015年期间，所有接受抗逆转录病毒治疗的病例中，超过90%的艾滋病毒得到抑制，表明艾滋病毒耐药性患病率较低。
中国东南部福建省的艾滋病毒/艾滋病疫情仍呈上升趋势。然而，该省艾滋病毒/艾滋病的流行病学模式最近发生了变化，因此应实施针对艾滋病毒/艾滋病流行病学特征变化的有效控制干预措施，以控制疫情的传播。
Zotero 插件
