Dahiya Neha, Acharya Anita S, Bachani Damodar, Sharma Dn, Gupta Subhash, Haresh Kp, Rath Gk
Department of Community Medicine, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India Email :
Asian Pac J Cancer Prev. 2016;17(7):3095-9.
Cervical cancer is the most frequently diagnosed cancer among women in India. Understanding quality of life (QOL) in women undergoing chemoradiotherapy for cervical cancer will help in introducing interventions for better care and outcomes in these women. This study assessed QOL before and after chemo radiotherapy in cervical cancer patients.
This followup study covered sixtyseven newly diagnosed women with advanced cervical cancer (stages 2b to 4b). Structured questionnaires (the European Organization for Research and Treatment of Cancer, EORTC QLQC30 and EORTC QLQCX24) were used to assess the change in QOL after 6 months of treatment.
The mean age of women at the time of detection of cervical cancer was 52.3±11.29 years (Range 3075 years). Six months survival was 92.53%. The mean global health score of cervical cancer patients after six months of treatment was 59.52, which was significantly higher than the pretreatment score of 50.15 (p=0.00007). Physical, cognitive and emotional functioning improved significantly (p<0.05) after treatment. Fatigue, pain, insomnia and appetite loss improved but episodes of diarrhea increased after treatment. The mean "symptoms score" using EORTC QLQCX24 post treatment was 20.0 which was significantly lower as compared to the pre treatment score 30.0 (p<0.00001). Sexual enjoyment and sexual functioning decreased significantly after treatment.
QOL of newly diagnosed cervical cancer patients improved significantly following chemoradio therapy. Enhancement was also demonstrated on three of the five functional scales of EORTC QLQC30. To further improve QOL, interventions focusing on social and psychological support and physical rehabilitation may be needed.
宫颈癌是印度女性中最常被诊断出的癌症。了解接受宫颈癌放化疗的女性的生活质量（QOL），将有助于采取干预措施，为这些女性提供更好的护理并改善治疗结果。本研究评估了宫颈癌患者放化疗前后的生活质量。
这项随访研究涵盖了67名新诊断的晚期宫颈癌（2b至4b期）女性。使用结构化问卷（欧洲癌症研究与治疗组织，EORTC QLQC30和EORTC QLQCX24）评估治疗6个月后生活质量的变化。
宫颈癌确诊时女性的平均年龄为52.3±11.29岁（范围30 - 75岁）。6个月生存率为92.53%。治疗6个月后宫颈癌患者的平均总体健康评分为59.52，显著高于治疗前的50.15分（p = 0.00007）。治疗后身体、认知和情感功能显著改善（p < 0.05）。疲劳、疼痛、失眠和食欲减退有所改善，但治疗后腹泻发作次数增加。使用EORTC QLQCX24治疗后的平均“症状评分”为20.0，与治疗前评分30.0相比显著降低（p < 0.00001）。治疗后性快感和性功能显著下降。
新诊断的宫颈癌患者放化疗后生活质量显著改善。EORTC QLQC30的五个功能量表中的三个也显示出改善。为进一步提高生活质量，可能需要侧重于社会和心理支持以及身体康复的干预措施。
