Ikoma Toshikazu, Kapoor Vinay Kumar, Behari Anu, Mishra Kumudesh, Tsuchiya Yasuo, Asai Takao, Endoh Kazuo, Okano Kiyoshi, Nakamura Kazutoshi
New Faculty Installation Preparation Room, Hokuriku University, Kanazawa, Japan Email :
Asian Pac J Cancer Prev. 2016;17(7):3499-503.
Our recent studies conducted in South America have shown that mycotoxin contamination of red chili peppers (RCPs) may be associated with an increased risk of gallbladder cancer (GBC). Whether this relationship exists in India, a country with a high incidence of GBC and high consumption of RCPs, is unclear. We therefore measured concentrations of aflatoxins (AFs) and ochratoxin A (OTA) in RCPs from areas of low, medium, and high incidence of GBC in India, and compared these concentrations with GBC incidence in each area. Twentyone RCP samples were collected from nine cities (eight from a lowincidence area, five from a mediumincidence area, and eight from a highincidence area). Concentrations of AFs and OTA were measured using highperformance liquid chromatography. No significant differences in mean concentrations of AFs and OTA were found in the three areas. AFB1 levels in the lowincidence area (10.81 ?g/kg) and highincidence area (12.00 ?g/kg) were more than 2.2 and 2.4 times higher compared with the maximum permitted level of AFB1 in spices (5.0 ?g/kg) set by the Commission of the European Communities, or that (4.4 ?g/kg) obtained in our previous study in Chile. Our results show that the mean concentrations of mycotoxins in RCPs are similar among the three areas in India with different incidences of GBC. Further studies with human subjects are needed to evaluate any association between AFB1 and GBC.
我们最近在南美洲开展的研究表明，红辣椒（RCP）中的霉菌毒素污染可能与胆囊癌（GBC）风险增加有关。在GBC发病率高且RCP消费量高的印度，这种关系是否存在尚不清楚。因此，我们测定了印度GBC低、中、高发病率地区RCP中黄曲霉毒素（AFs）和赭曲霉毒素A（OTA）的浓度，并将这些浓度与各地区的GBC发病率进行了比较。从9个城市收集了21个RCP样本（8个来自低发病率地区，5个来自中等发病率地区，8个来自高发病率地区）。使用高效液相色谱法测定AFs和OTA的浓度。在这三个地区，AFs和OTA的平均浓度没有显著差异。与欧洲共同体委员会规定的香料中AFB1的最大允许水平（5.0μg/kg）或我们之前在智利的研究中获得的水平（4.4μg/kg）相比，低发病率地区（10.81μg/kg）和高发病率地区（12.00μg/kg）的AFB1水平分别高出2.2倍和2.4倍以上。我们的结果表明，在印度GBC发病率不同的三个地区，RCP中霉菌毒素的平均浓度相似。需要对人类受试者进行进一步研究，以评估AFB1与GBC之间的任何关联。
