Fernández-Pérez María José, Alarcón José Antonio, McNamara James A, Velasco-Torres Miguel, Benavides Erika, Galindo-Moreno Pablo, Catena Andrés
Department of Orthodontics, School of Dentistry, University of Granada, Granada, Spain.
Department of Orthodontics and Pediatric Dentistry, School of Dentistry, The University of Michigan, Ann Arbor, Michigan, United States of America.
PLoS One. 2016 Aug 11;11(8):e0161104. doi: 10.1371/journal.pone.0161104. eCollection 2016.
The aim of this study was to determine the relationship between the closure stage of the spheno-occipital synchondrosis and the maturational stage of the cervical vertebrae (CVM) in growing and young adult subjects using cone beam computed tomography (CBCT). CBCT images with an extended field of view obtained from 315 participants (148 females and 167 males; mean age 15.6 ±7.3 years; range 6 to 23 years) were analyzed. The fusion status of the synchondrosis was determined using a five-stage scoring system; the vertebral maturational status was evaluated using a six-stage stratification (CVM method). Ordinal regression was used to study the ability of the synchondrosis stage to predict the vertebral maturation stage. Vertebrae and synchondrosis had a strong significant correlation (r = 0.89) that essential was similar for females (r = 0.88) and males (r = 0.89). CVM stage could be accurately predicted from synchondrosis stage by ordinal regression models. Prediction equations of the vertebral stage using synchondrosis stage, sex and biological age as predictors were developed. Thus this investigation demonstrated that the stage of spheno-occipital synchondrosis, as determined in CBCT images, is a reasonable indicator of growth maturation.
本研究的目的是使用锥形束计算机断层扫描（CBCT）确定生长发育期和年轻成年受试者蝶枕软骨结合的闭合阶段与颈椎成熟阶段（CVM）之间的关系。分析了从315名参与者（148名女性和167名男性；平均年龄15.6±7.3岁；范围6至23岁）获得的具有扩展视野的CBCT图像。使用五阶段评分系统确定软骨结合的融合状态；使用六阶段分层（CVM方法）评估椎体成熟状态。使用有序回归研究软骨结合阶段预测椎体成熟阶段的能力。椎体和软骨结合具有很强的显著相关性（r = 0.89），女性（r = 0.88）和男性（r = 0.89）基本相似。通过有序回归模型可以从软骨结合阶段准确预测CVM阶段。建立了以软骨结合阶段、性别和生物学年龄作为预测因子的椎体阶段预测方程。因此，本研究表明，CBCT图像中确定的蝶枕软骨结合阶段是生长成熟的合理指标。
