Çolak Bayram, Şakalak Hüseyin, Çavuşoğlu Halit, Yavuz Mustafa Selman
Department of General Surgery, Faculty of Medicine, Selcuk University, Konya, Turkey.
Advanced Technology Research and Application Center, Selcuk University, Konya, Turkey; Department of Metallurgy and Materials Engineering, Selcuk University, Konya, Turkey.
Med Hypotheses. 2016 Sep;94:99-102. doi: 10.1016/j.mehy.2016.07.006. Epub 2016 Jul 12.
Obscure gastrointestinal (GI) bleeding is identified as persistent or repeated bleeding from the gastrointestinal tract which could not be defined by conventional gastrointestinal endoscopy and radiological examinations. These GI bleedings are assessed through invasive diagnostic and treatment methods including enteroscopy, angiography and endoscopy. In addition, video capsule endoscopy (VCE) is a non-invasive method used to determine the location of the bleeding, however, this does not provide any treatment. Despite of these successful but invasive methods, an effective non-invasive treatment is desperately needed. Herein, we prepare non-invasive theranostic capsules to cure obscure GI bleeding. An effective theranostic capsule containing endothelin as the targeting agent, thrombin-fibrinogen or fibrin as the treating agent, and fluorescein dye as the diagnostic tool is suggested. These theranostic capsules can be administered orally in a simple and non-invasive manner without a risk of complication. By using these novel capsules, one can diagnose obscure GI bleeding with having a possibility of curing.
隐匿性胃肠道出血被定义为胃肠道持续或反复出血，而传统的胃肠道内镜检查和放射学检查无法明确其病因。这些胃肠道出血通过包括小肠镜检查、血管造影和内镜检查在内的侵入性诊断和治疗方法进行评估。此外，视频胶囊内镜（VCE）是一种用于确定出血位置的非侵入性方法，然而，它不能提供任何治疗。尽管有这些成功但具有侵入性的方法，但迫切需要一种有效的非侵入性治疗方法。在此，我们制备了用于治疗隐匿性胃肠道出血的非侵入性诊疗胶囊。提出了一种有效的诊疗胶囊，其包含内皮素作为靶向剂、凝血酶-纤维蛋白原或纤维蛋白作为治疗剂以及荧光素染料作为诊断工具。这些诊疗胶囊可以以简单且非侵入性的方式口服给药，且无并发症风险。通过使用这些新型胶囊，人们可以在有可能治愈的情况下诊断隐匿性胃肠道出血。
