Okuzumi Shinichi, Minematsu Naoto, Sasaki Mamoru, Ohsawa Kazuma, Murakami Marohito
Department of Medicine Hino Municipal Hospital Tokyo Japan.
Respirol Case Rep. 2016 Jul 5;4(5):e00176. doi: 10.1002/rcr2.176. eCollection 2016 Sep.
Mycobacterium avium complex (MAC) infection is a major medical concern in Japan because of its increased prevalence and associated mortality. A common radiological feature in pulmonary MAC infection is a mixture of two basic patterns: fibrocavitary and nodular bronchiectatic; however, lobar consolidation is rare. We report an 83-year-old man with lobar caseous pneumonia caused by pulmonary MAC infection. Radiological findings were predominantly composed of dense lobar consolidation and ground-glass opacity. A diagnosis was made in accordance with the clinical and microbiological criteria set by the American Thoracic Society. A histological examination of lung specimens obtained by using a bronchoscope revealed a caseous granulomatous inflammation with an appearance of Langhans cells. The patient was treated using combined mycobacterium chemotherapy with an initial positive response for 6 months; however, the disease progressed later. We suggest that an awareness of lobar pneumonic consolidation as a rare radiological finding in pulmonary MAC infection is important.
鸟分枝杆菌复合群(MAC)感染在日本是一个主要的医学问题,因为其患病率上升且伴有死亡率。肺部MAC感染常见的放射学特征是两种基本模式的混合:纤维空洞型和结节支气管扩张型;然而,大叶实变很少见。我们报告一例83岁男性因肺部MAC感染导致大叶干酪性肺炎。放射学表现主要为致密的大叶实变和磨玻璃影。根据美国胸科学会制定的临床和微生物学标准做出诊断。通过支气管镜获取的肺标本组织学检查显示为具有朗汉斯细胞外观的干酪性肉芽肿性炎症。患者接受联合分枝杆菌化疗,最初6个月有阳性反应;然而,疾病后来进展。我们认为,认识到大叶肺炎实变作为肺部MAC感染中一种罕见的放射学表现很重要。