胆汁酸类似物阻断肝纤维化。
Bile Acid Analog Intercepts Liver Fibrosis.
作者信息
De Magalhaes Filho C Daniel, Downes Michael, Evans Ron
机构信息
Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
出版信息
Cell. 2016 Aug 11;166(4):789. doi: 10.1016/j.cell.2016.08.001.
PMID:27518554
Abstract
Ocaliva, a synthetic bile acid analog with high affinity for the nuclear bile acid receptor FXR, is effective in treating primary biliary cholangitis, an autoimmune liver disease. It works in patients who fail to respond to or cannot tolerate conventional treatment with the natural bile acid ursodeoxycholic acid (UDCA).
摘要
奥贝胆酸是一种对核胆汁酸受体FXR具有高亲和力的合成胆汁酸类似物，对治疗原发性胆汁性胆管炎（一种自身免疫性肝病）有效。它适用于对天然胆汁酸熊去氧胆酸（UDCA）常规治疗无反应或无法耐受的患者。
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