Jiang Xuejiao, Li Zhao, Yao Jinrong, Shao Zhengzhong, Chen Xin
State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Polymers and Polymer Composite Materials, Department of Macromolecular Science, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, People's Republic of China.
State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Polymers and Polymer Composite Materials, Department of Macromolecular Science, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, People's Republic of China.
Mater Sci Eng C Mater Biol Appl. 2016 Nov 1;68:798-804. doi: 10.1016/j.msec.2016.07.034. Epub 2016 Jul 18.
Photothermal therapy, due to its security and effectiveness, has recently become a promising cancer treatment after surgery, radiotherapy, chemotherapy, and biological therapy. In this article, soy protein isolate/reduced graphene oxide (SPI/rGO) nanocomposites are prepared via a simple and green process. That is, GO is reduced in situ and stabilized by SPI, an abundant, low-cost, sustainable natural material, and simultaneously forms SPI/rGO nanocomposites. The resulting SPI/rGO nanocomposites disperse in water very well and exhibit good biocompatibility due to the attachment of SPI to the surface of rGO. Such SPI/rGO nanocomposites demonstrate an excellent photothermal capacity and are able to kill HeLa cells efficiently with near-infrared irradiation (808nm). The results in this work suggest that such a SPI/rGO hybrid material could be a promising candidate for future applications of photothermal therapy.
光热疗法因其安全性和有效性，最近已成为继手术、放疗、化疗和生物疗法之后一种很有前景的癌症治疗方法。在本文中，通过一种简单且绿色的工艺制备了大豆分离蛋白/还原氧化石墨烯（SPI/rGO）纳米复合材料。也就是说，氧化石墨烯（GO）通过丰富、低成本、可持续的天然材料SPI原位还原并稳定化，同时形成SPI/rGO纳米复合材料。所得的SPI/rGO纳米复合材料在水中分散性很好，并且由于SPI附着在rGO表面而表现出良好的生物相容性。这种SPI/rGO纳米复合材料展现出优异的光热性能，并且能够在近红外照射（808nm）下有效杀死HeLa细胞。这项工作的结果表明，这种SPI/rGO杂化材料可能是光热疗法未来应用的一个有前景的候选材料。
