Department of Biomaterials/Biomedical Engineering Research Centre, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China.
Nanotechnology. 2017 Jul 21;28(29):295102. doi: 10.1088/1361-6528/aa761b. Epub 2017 Jun 28.
For releasing both drug and heat to selected sites, a combination of chemotherapy and photothermal therapy in one system is a more effective way to destroy cancer cells than monotherapy. Graphene oxide (GO) with high drug-loading efficiency and near-infrared (NIR) absorbance has great potential in drug delivery and photothermal therapy, but it is difficult to load drugs with high solubility. Herein, we develop a versatile drug delivery nanoplatform based on GO for integrated chemotherapy and photothermal therapy by a facile method of simultaneous reduction and surface functionalization of GO with poly(dopamine) (PDA). Due to the excellent adhesion of PDA, both low and high solubility drugs can be encapsulated in the PDA-functionalized GO nanocomposite (rGO-PDA). The fabricated nanocomposite exhibits good biocompatibility, excellent photothermal performance, high drug loading capacity, an outstanding sustained release property, and efficient endocytosis. Moreover, NIR laser irradiation facilitates the release of loaded drugs from rGO-PDA. These features make the rGO-PDA nanocomposite achieve excellent in vivo synergistic antitumor therapeutic efficacy.
为了将药物和热量释放到选定的部位，将化疗和光热疗法结合在一个系统中是比单一疗法更有效地破坏癌细胞的方法。具有高载药效率和近红外（NIR）吸收的氧化石墨烯（GO）在药物输送和光热治疗方面具有很大的潜力，但很难负载高溶解度的药物。在此，我们通过将 GO 与聚多巴胺（PDA）同时还原和表面功能化的简便方法，开发了一种基于 GO 的多功能药物输送纳米平台，用于集成化疗和光热治疗。由于 PDA 的优异粘附性，低溶解度和高溶解度的药物都可以被封装在 PDA 功能化的 GO 纳米复合材料（rGO-PDA）中。所制备的纳米复合材料具有良好的生物相容性、优异的光热性能、高载药能力、出色的缓释性能和高效的内吞作用。此外，近红外激光照射促进了 rGO-PDA 中负载药物的释放。这些特性使 rGO-PDA 纳米复合材料实现了出色的体内协同抗肿瘤治疗效果。
