Zheng Wei, Wang Qilan, Lu Xiaohua, Shi Qiangqiang, Zou Junhui, Tao Yanduo, Wang Pu
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Institute of Military Veterinary Medicine, Academy of Military Medical Science, Changchun 130122, China.
Northwest Plateau Institute of Biology, Chinese Academy of Sciences, Xining 810001, China.
Mediators Inflamm. 2016;2016:2684321. doi: 10.1155/2016/2684321. Epub 2016 Jul 25.
Dracocephalum heterophyllum (DH) is a Chinese herbal medicine used in treating hepatitis. However, the protective effects and pharmacological mechanisms of DH in hepatitis are unknown. In this study, we found that pretreatment with DH extract significantly ameliorated liver injury and suppressed the production of inflammatory cytokines, including tumor necrosis factor (TNF-α) and interferon-γ (IFN-γ) in Concanavalin A- (ConA-) induced hepatitis (CIH). DH recruited more CD11b(+) Gr1(+) myeloid-derived suppressor cells (MDSCs) to the liver and suppressed infiltration of macrophages (Kupffer cells) in the liver. The present work explores DH as an effective hepatoprotective medicine to inhibit inflammation and liver injury caused by hepatitis.
异叶青兰是一种用于治疗肝炎的中草药。然而，异叶青兰在肝炎中的保护作用和药理机制尚不清楚。在本研究中，我们发现用异叶青兰提取物预处理可显著改善肝损伤，并抑制刀豆蛋白A（ConA）诱导的肝炎（CIH）中炎性细胞因子的产生，包括肿瘤坏死因子（TNF-α）和干扰素-γ（IFN-γ）。异叶青兰招募更多的CD11b(+)Gr1(+)髓源性抑制细胞（MDSCs）至肝脏，并抑制肝脏中巨噬细胞（库普弗细胞）的浸润。本研究探讨了异叶青兰作为一种有效的保肝药物来抑制肝炎引起的炎症和肝损伤。
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