Weremczuk-Jeżyna Izabela, Grzegorczyk-Karolak Izabela
Department of Biology and Pharmaceutical Botany, Medical University of Lodz, 90-151 Lodz, Poland.
Molecules. 2025 Apr 30;30(9):2017. doi: 10.3390/molecules30092017.
The genus (family Lamiaceae) comprises approximately 70 species, many of which have been traditionally used in various ethnomedical systems. The plants exhibit a broad distribution across steppe, semi-deserts, deserts, and alpine zones of temperate Eurasia, with isolated endemic species occurring in North America and North Africa. The traditional medicinal uses of the species encompass the treatment of respiratory diseases, colds and fever, gastrointestinal disorders, liver and gallbladder ailments, musculoskeletal conditions, cardiovascular diseases, diabetes, gynecological and urological disorders, as well as ailments of the ears, throat, mouth, and eyes, as well as various dermatological conditions. The plants are rich sources of polyphenolic compounds, including flavonoids and phenolic acids, which contribute to their diverse pharmacological activities. The flavonoid profile of the species is dominated by luteolin and apigenin derivatives, supplemented by mono-, di-, tri-, tetra-, and pentamethoxylated flavones. The predominant phenolic acids are chlorogenic acid, coumaric acid, rosmarinic acid, and their derivatives. Other phenolic compounds have also been identified in the genus: anthocyanins, lignans, phenylethanoids, phenylacetamide glycosides, flavonoid alkaloids, gingerols, coumarins, furanocoumarins, and cyanogenic glucosides. Despite growing scientific interest in this genus, a comprehensive review of its polyphenolic constituents, their structures, and associated biological activities remains lacking. To bridge this gap, this review presents an analysis of the polyphenolic profile of the species, their ethnomedicinal uses, and the latest findings on their biological potential.
[该属植物（唇形科）约有70个物种，其中许多在各种民族医学体系中都有传统应用。这些植物广泛分布于欧亚大陆温带的草原、半沙漠、沙漠和高山地带，在北美和北非也有孤立的特有物种。该属植物的传统药用用途包括治疗呼吸道疾病、感冒和发烧、胃肠道疾病、肝胆疾病、肌肉骨骼疾病、心血管疾病、糖尿病、妇科和泌尿系统疾病，以及耳、喉、口、眼疾病，还有各种皮肤病。这些植物富含多酚类化合物，包括黄酮类化合物和酚酸，这促成了它们多样的药理活性。该属植物的黄酮类化合物谱以木犀草素和芹菜素衍生物为主，还有单甲氧基、二甲氧基、三甲氧基、四甲氧基和五甲氧基黄酮作为补充。主要的酚酸是绿原酸、香豆酸、迷迭香酸及其衍生物。该属中还鉴定出了其他酚类化合物：花青素、木脂素、苯乙醇类、苯乙酰胺糖苷、黄酮生物碱、姜辣素、香豆素、呋喃香豆素和氰苷。尽管对该属植物的科学兴趣日益浓厚，但仍缺乏对其多酚成分、结构及相关生物活性的全面综述。为填补这一空白，本综述对该属植物的多酚谱、民族药用用途及其生物潜力的最新研究结果进行了分析。] 需注意，原文中“ The genus (family Lamiaceae)”这里属名缺失，我按常规处理方式翻译了，实际应用中请根据准确属名进行调整。
