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旱芹对刀豆蛋白诱导的急性肝炎具有抗炎活性。

Lepidium meyenii Walp Exhibits Anti-Inflammatory Activity against ConA-Induced Acute Hepatitis.

机构信息

Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Science, Changchun 130122, China.

2nd Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China.

出版信息

Mediators Inflamm. 2018 Dec 16;2018:8982756. doi: 10.1155/2018/8982756. eCollection 2018.

DOI:10.1155/2018/8982756
PMID:30647537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6311815/
Abstract

Strong inflammation is a prominent pathogenesis of acute hepatitis, which can induce hepatocyte death and lead to liver failure. Lepidium meyenii Walp (Maca) is a traditional herbal medicine mostly used in improving sperm motility and serum hormone levels, etc. However, there are no reports that showed Maca was designed for treating hepatitis so far. Therefore, the protective effects and pharmacological mechanisms of Maca are unknown in hepatitis. In this study, we found that the protective effects of Maca extract ameliorate ConA-induced acute hepatitis (CIH) and underlying mechanisms. We determined that pretreatment with Maca extract significantly suppressed the production of aminotransferases and inflammatory cytokines, including IFN-, TNF-, IL-1, IL-2, IL-6, IL-12, and IL-17a, and moderated acute liver injury in CIH. Maca recruited more myeloid-derived suppressor cells (MDSCs) to the liver and suppressed infiltration of natural killer T cells (NKT cells) and macrophages in the liver. Furthermore, our data indicated the molecular mechanism of the inhibitory inflammatory effects of Maca, which should suppress the activation of NF-B, IFN-/STAT1, and IL-6/STAT3 signalings. Collectively, this present research explores Maca as an effective hepatoprotective medicine to inhibit inflammation and liver injury caused by acute hepatitis.

摘要

强烈的炎症是急性肝炎的一个突出发病机制，它可诱导肝细胞死亡，导致肝功能衰竭。Lepidium meyenii Walp（玛咖）是一种传统的草药，主要用于提高精子活力和血清激素水平等。然而，迄今为止，尚无报道表明玛咖是专门用于治疗肝炎的。因此，玛咖在肝炎中的保护作用和药理机制尚不清楚。在这项研究中，我们发现玛咖提取物的保护作用可改善伴刀豆球蛋白 A（ConA）诱导的急性肝炎（CIH），并阐明了其潜在机制。我们确定，玛咖提取物预处理可显著抑制氨基转移酶和炎症细胞因子的产生，包括 IFN-γ、TNF-α、IL-1、IL-2、IL-6、IL-12 和 IL-17a，并可改善 CIH 中的急性肝损伤。玛咖可募集更多的髓源抑制细胞（MDSCs）到肝脏，并抑制自然杀伤 T 细胞（NKT 细胞）和巨噬细胞在肝脏中的浸润。此外，我们的数据表明了玛咖抑制炎症作用的分子机制，其可能抑制 NF-κB、IFN-/STAT1 和 IL-6/STAT3 信号通路的激活。综上所述，本研究探索了玛咖作为一种有效的肝保护药物，可抑制急性肝炎引起的炎症和肝损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7c/6311815/e0111b5d7f98/MI2018-8982756.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7c/6311815/96111fd675e5/MI2018-8982756.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7c/6311815/ee3eb53f1804/MI2018-8982756.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7c/6311815/78f8acd3ebf4/MI2018-8982756.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7c/6311815/2fb4430b2704/MI2018-8982756.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7c/6311815/76ff3388965c/MI2018-8982756.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7c/6311815/e0111b5d7f98/MI2018-8982756.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7c/6311815/96111fd675e5/MI2018-8982756.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7c/6311815/ee3eb53f1804/MI2018-8982756.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7c/6311815/78f8acd3ebf4/MI2018-8982756.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7c/6311815/2fb4430b2704/MI2018-8982756.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7c/6311815/76ff3388965c/MI2018-8982756.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7c/6311815/e0111b5d7f98/MI2018-8982756.006.jpg

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