一种来自大戟科大戟属植物斯特雷奇大戟的新对映-贝壳杉烷二萜。

A new ent-kaurane diterpene from Euphorbia stracheyi Boiss.

作者信息

Liu Tie, Liang Qian, Xiong Na-Na, Dai Lin-Feng, Wang Jun-Ming, Ji Xiao-Hui, Xu Wen-Hui

机构信息

a Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China , Ministry of Education, Southwest Forestry University , Kunming , P.R. China.

b Department of Medicinal Plant, School of Forestry , Southwest Forestry University , Kunming , P.R. China.

出版信息

Nat Prod Res. 2017 Jan;31(2):233-238. doi: 10.1080/14786419.2016.1222385. Epub 2016 Aug 17.

DOI:10.1080/14786419.2016.1222385

PMID:27531560

Abstract

The chemical investigation of whole plants Euphorbia stracheyi Boiss from China led to the isolation of one new ent-kaurane diterpene, ent-Kaurane-16β,17,19-triol-3-one (1), along with three known ent-kaurane diterpenoids (2-4) as ent-Kaurane-3α,16β,17-triol (2)，ent-16S,17-dihydroxy-kaurane-3-one (3) and ent-3S,16S,17-trihydroxy-kaurane-2-one (4). Their structures were elucidated by extensive spectroscopic analyses including 1D, 2D NMR, HR-ESI-MS, and by comparison with the literature. Compound 2 was a new natural product and firstly isolated from nature, while compounds (3-4) were isolated from E. stracheyi for the first time. All isolated compounds (1-4) were evaluated for their cytotoxic activities against five human cancer cell lines (including A-549, SMMC-7721, HL-60, MCF-7 and SW-480).

摘要

对中国产的全株西藏大戟（Euphorbia stracheyi Boiss）进行化学研究，从中分离得到一个新的对映-贝壳杉烷二萜，对映-贝壳杉烷-16β,17,19-三醇-3-酮（1），以及三个已知的对映-贝壳杉烷二萜类化合物（2 - 4），即对映-贝壳杉烷-3α,16β,17-三醇（2）、对映-16S,17-二羟基-贝壳杉烷-3-酮（3）和对映-3S,16S,17-三羟基-贝壳杉烷-2-酮（4）。通过包括一维、二维核磁共振、高分辨电喷雾电离质谱在内的广泛光谱分析，并与文献进行比较，阐明了它们的结构。化合物2是一种新的天然产物，首次从自然界中分离得到，而化合物（3 - 4）是首次从西藏大戟中分离得到。对所有分离得到的化合物（1 - 4）针对五种人类癌细胞系（包括A - 549、SMMC - 7721、HL - 60、MCF - 7和SW - 480）进行了细胞毒性活性评估。