高频刺激诱导的背侧和腹侧海马CA1区突触增强：NMDA受体、代谢型谷氨酸受体5（mGluR5）和（L型）电压门控钙通道的作用
High-frequency stimulation-induced synaptic potentiation in dorsal and ventral CA1 hippocampal synapses: the involvement of NMDA receptors, mGluR5, and (L-type) voltage-gated calcium channels.
作者信息
Papatheodoropoulos Costas, Kouvaros Stylianos
机构信息
Laboratory of Physiology, Department of Medicine, University of Patras, 26504, Rion, Greece
Laboratory of Physiology, Department of Medicine, University of Patras, 26504, Rion, Greece.
出版信息
Learn Mem. 2016 Aug 16;23(9):460-4. doi: 10.1101/lm.042531.116. Print 2016 Sep.
Abstract
The ability of the ventral hippocampus (VH) for long-lasting long-term potentiation (LTP) and the mechanisms underlying its lower ability for short-lasting LTP compared with the dorsal hippocampus (DH) are unknown. Using recordings of field excitatory postsynaptic potentials (EPSPs) from the CA1 field of adult rat hippocampal slices, we found that 200-Hz stimulation induced nondecremental LTP that was maintained for at least 7 h and was greater in the DH than in the VH. The interaction of NMDA receptors with L-type voltage-dependent calcium channels appeared to be more effective in the DH than in the VH. Furthermore, the LTP was significantly enhanced in the DH only, between 2 and 5 h post-tetanus. Furthermore, the mGluR5 contributed to the post-tetanic potentiation more in the VH than in the DH.
摘要
腹侧海马体（VH）产生持久长时程增强（LTP）的能力，以及与背侧海马体（DH）相比其产生短时程LTP能力较低的潜在机制尚不清楚。通过记录成年大鼠海马切片CA1区的场兴奋性突触后电位（EPSP），我们发现200Hz刺激诱导了非递减性LTP，该LTP持续至少7小时，且在DH中比在VH中更强。NMDA受体与L型电压依赖性钙通道的相互作用在DH中似乎比在VH中更有效。此外，仅在强直后2至5小时，DH中的LTP显著增强。此外，代谢型谷氨酸受体5（mGluR5）在VH中比在DH中对强直后增强的作用更大。
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