Jiang Jia-yao, Lu Xu-hua
Zhongguo Gu Shang. 2016 Jun;29(6):576-80.
Neck shoulder pain or lumbocrural pain caused by intervertebral disc degeneration (IDD) could seriously affect the qualities life of patients. Current treatments mainly focus on alleviating pain and the symptoms of nerve compression, which could not radically stop the process of intervertebral disc degeneration, but conversely lead to high recurrence rate. In recent years, scholars have turned to study the biological treatment for repair and rebuild the intervertebral disc by biological molecular therapy, gene therapy, cell therapy and tissue engineering to solve the problem of intervertebral disc degeneration, while most of the above methods are still in animal experiments or in vitro experiments and the clinical application is still a long way to go.
椎间盘退变(IDD)引起的颈肩痛或腰腿痛会严重影响患者的生活质量。目前的治疗主要集中在缓解疼痛和神经受压症状,这无法从根本上阻止椎间盘退变的进程,反而导致高复发率。近年来,学者们转而研究通过生物分子疗法、基因疗法、细胞疗法和组织工程对椎间盘进行修复和重建的生物治疗方法来解决椎间盘退变问题,而上述大多数方法仍处于动物实验或体外实验阶段,临床应用仍有很长的路要走。