Yoon Mee-Sup, Choi Cheol Soo
Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, Korea.
Korea Mouse Metabolic Phenotyping Center (KMMPC), Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea.
Exp Mol Med. 2016 Jan 8;48(1):e201. doi: 10.1038/emm.2015.93.
Mammalian target of rapamycin (mTOR) controls cell growth and metabolism in response to nutrients, energy, and growth factors. Recent findings have placed the lysosome at the core of mTOR complex 1 (mTORC1) regulation by amino acids. Two parallel pathways, Rag GTPase-Ragulator and Vps34-phospholipase D1 (PLD1), regulate mTOR activation on the lysosome. This review describes the recent advances in understanding amino acid-induced mTOR signaling with a particular focus on the role of mTOR in insulin resistance.
雷帕霉素哺乳动物靶蛋白（mTOR）可根据营养物质、能量和生长因子来控制细胞生长与代谢。最近的研究发现，溶酶体是氨基酸对mTOR复合物1（mTORC1）调控的核心。两条平行途径，即Rag GTP酶-Ragulator和Vps34-磷脂酶D1（PLD1），在溶酶体上调节mTOR的激活。本综述描述了在理解氨基酸诱导的mTOR信号传导方面的最新进展，特别关注mTOR在胰岛素抵抗中的作用。
