黄荆变种（Vitex negundo var. heterophylla）的成分及其对一氧化氮产生的抑制作用。
Constituents from Vitex negundo var. heterophylla and their inhibition of nitric oxide production.
作者信息
Qiu Chongyue, Tong Liang, Yuan Ting, Wang Fei, Zhao Feng, Chen Lixia
机构信息
Key Laboratory of Structure-Based Drug Design and Discovery, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.
School of Pharmacy, Yantai University, Yantai, 264005, China.
出版信息
J Nat Med. 2017 Jan;71(1):292-298. doi: 10.1007/s11418-016-1032-y. Epub 2016 Aug 17.
An iridoid glucoside, 10-p-hydroxybenzoyl-6β-hydroxyiridoid 1-O-β-D-(6'-O-p-hydroxybenzoyl)-glucopyranoside (1), and a phenol glucoside, 4-hydroxyphenethanol 3-O-β-D-(6'-O-p-hydroxybenzoyl)-glucopyranoside (2), along with nine known compounds (3-11) were isolated from the dried leaves of Vitex negundo var. heterophylla. Their structures were elucidated by extensive analysis of NMR spectra. All of the isolated compounds were evaluated for their inhibitory effects on nitric oxide production in RAW 264.7 macrophages. Compounds 2 and 3 exhibited obvious inhibitory effects on NO production with IC values of 30.76 and 49.89 μM, respectively. Molecular docking studies of compounds 2 and 3 with nitric oxide synthase (NOS) further confirmed the above results.
从黄荆变种异叶黄荆的干燥叶中分离得到一种环烯醚萜苷，10 - 对羟基苯甲酰基 - 6β - 羟基环烯醚萜1 - O - β - D -（6'-O - 对羟基苯甲酰基） - 吡喃葡萄糖苷（1），一种酚苷，4 - 羟基苯乙醇3 - O - β - D -（6'-O - 对羟基苯甲酰基） - 吡喃葡萄糖苷（2），以及9种已知化合物（3 - 11）。通过对核磁共振谱的广泛分析阐明了它们的结构。对所有分离得到的化合物进行了对RAW 264.7巨噬细胞中一氧化氮产生的抑制作用评估。化合物2和3对一氧化氮产生表现出明显的抑制作用，IC值分别为30.76和49.89 μM。化合物2和3与一氧化氮合酶（NOS）的分子对接研究进一步证实了上述结果。
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