三叶牡荆中的三萜类化合物及其抗炎活性。
Terpenoids from Vitex trifolia and their anti-inflammatory activities.
机构信息
Wuya College of Innovation, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
出版信息
J Nat Med. 2018 Mar;72(2):570-575. doi: 10.1007/s11418-018-1178-x. Epub 2018 Feb 10.
A new diterpenoid glucoside, (3S,5S,6S,8R,9R,10S)-3,6,9-trihydroxy-13(14)-labdean-16,15-olide 3-O-β-D-glucopyranoside (1), and a new iridoid glucoside, (1S, 5S,6R,9R)-10-O-p-hydroxybenzoyl-5,6β-dihydroxy iridoid 1-O-β-D-glucopyranoside (2), along with six known compounds (3-8) were isolated from Vitex trifolia L.. Their structures were elucidated by extensive spectroscopic analysis. All these isolated compounds were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 macrophages. Compounds 2, 4, 5, and 7 showed moderate inhibitory activities with IC values of 90.05, 88.51, 87.26, and 76.06 μM, respectively.
从三叶荆芥（Vitex trifolia L.）中分离得到了一个新的二萜苷类化合物（3S,5S,6S,8R,9R,10S）-3,6,9-三羟基-13(14)-labdean-16,15-内酯 3-O-β-D-吡喃葡萄糖苷（1）和一个新的环烯醚萜苷类化合物（1S, 5S,6R,9R）-10-O-对羟基苯甲酰基-5,6β-二羟基环烯醚萜 1-O-β-D-吡喃葡萄糖苷（2），以及另外 6 个已知化合物（3-8）。通过广泛的光谱分析确定了它们的结构。所有这些分离得到的化合物都被评估了对 LPS 诱导的 RAW 264.7 巨噬细胞中一氧化氮产生的抑制作用。化合物 2、4、5 和 7 表现出中等抑制活性，IC 值分别为 90.05、88.51、87.26 和 76.06 μM。
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