[中华苦荬菜根的化学成分]

[Chemical constituents from roots of Ixeris chinensis].

作者信息

Zhang Shu-Jun, Wang Dan, XUu Ce, Wang Jin-Lan, Zhao Ming

出版信息

Zhongguo Zhong Yao Za Zhi. 2014 Aug;39(16):3089-93.

Abstract

Silica gel column chromatography and preparative HPLC were applied to isolate the chemical constituents from the roots of Ixeris chinensis. Fifteen compounds were isolated and their structures were elucidated by the physicochemical properties and spectral analysis as chinensioide G(1), chinensioide B(2), 10α-hydroxy-guaia-12,6-lactone-3-keton(3), chinensioide C(4), 10α-hydroxy-11βH-guaia-4(5) -ene-12,6-lactone (5), 3β, 10α-dihydroxy-11βH-guaia-11 (13)-ene-12,6-lactone (6), 3β, 10α-dihydroxy-4βH, 11βH-guaia-12,6-lactone(7), 3β, 10α-dihydroxy-guaia-4 (15), 11 (13) -diene-12, 6-lactone (8), caffeic acid (9), p-hydorxyphenylacetic acid(10), methyl p-hydroxyphenylacetate (11), ethyl p-hydroxyphenylacetate (12), sitosterol (13), daucosterol (14), and ixerin D(15). Compound 1 was new, and 6 and 7 were isolated from I. chinensis for the first time.

摘要

采用硅胶柱色谱和制备型高效液相色谱法从中华苦荬菜的根中分离化学成分。分离得到15个化合物，通过理化性质和光谱分析鉴定其结构为中华苦荬菜内酯G(1)、中华苦荬菜内酯B(2)、10α-羟基愈创木-12,6-内酯-3-酮(3)、中华苦荬菜内酯C(4)、10α-羟基-11βH-愈创木-4(5)-烯-12,6-内酯(5)、3β,10α-二羟基-11βH-愈创木-11(13)-烯-12,6-内酯(6)、3β,10α-二羟基-4βH,11βH-愈创木-12,6-内酯(7)、3β,10α-二羟基-愈创木-4(15),11(13)-二烯-12,6-内酯(8)、咖啡酸(9)、对羟基苯乙酸(10)、对羟基苯乙酸甲酯(11)、对羟基苯乙酸乙酯(12)、甾醇(13)、胡萝卜苷(14)和苦荬菜苷D(15)。化合物1为新化合物，化合物6和7首次从中华苦荬菜中分离得到。