结核病感染与抗肿瘤坏死因子治疗：银屑病患者的筛查挑战
Tuberculosis infection versus anti-tumor necrosis factor therapy: screening challenges in psoriatic patients.
作者信息
Solovan Caius, Chiticariu Elena, Timofte Adelina, Stoia-Djeska Irina
机构信息
Department of Dermatology, University of Medicine and Pharmacy "Victor Babeş", TimisoaraRomania.
Department of Dermatology, County Hospital, TimişoaraRomania.
出版信息
J Drug Assess. 2012 Oct 26;1(1):65-7. doi: 10.3109/21556660.2012.744315. eCollection 2012.
OBJECTIVES
The aim of this study was to analyze the performance of the tuberculin skin test (TST) for screening and monitoring patients treated with anti-tumor necrosis factor agents, in a high-incidence area.
METHODS
A 3-year retrospective study was carried out on 268 subjects. The study included 68 patients with moderate-to-severe psoriasis, screened for latent tuberculosis infection (LTBI) and subjects without psoriasis (100 adults and 100 children) with close contact with infected individuals.
RESULTS
Positive tuberculin skin test (TST) results (induration >5 mm) were observed in 70.5% (48/68) of patients with psoriasis, higher than those observed in subjects with suspicion of tuberculosis or with close contact with infected individuals: 51% (51/100) in the adult group and 30% (30/100) in the children group.
CONCLUSIONS
These results show that the prevalence of LTBI evaluated with the TST in the psoriatic group is higher than in subjects without psoriasis.
LIMITATION
The positive reactions were not confirmed by other verification methods.
目的
本研究旨在分析结核菌素皮肤试验（TST）在高发病率地区对接受抗肿瘤坏死因子药物治疗的患者进行筛查和监测的性能。
方法
对268名受试者进行了一项为期3年的回顾性研究。该研究包括68例中重度银屑病患者，对其进行潜伏性结核感染（LTBI）筛查，以及与感染个体有密切接触的无银屑病受试者（100名成人和100名儿童）。
结果
银屑病患者中70.5%（48/68）的结核菌素皮肤试验（TST）结果呈阳性（硬结>5mm），高于疑似结核病患者或与感染个体密切接触的受试者：成人组为51%（51/100），儿童组为30%（30/100）。
结论
这些结果表明，银屑病组中通过TST评估的LTBI患病率高于无银屑病的受试者。
局限性
阳性反应未通过其他验证方法得到证实。
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