Suslova K G, Sokolova A B, Tolmachev S Yu, Miller S C
Southern Urals Biophysics Institute (SUBI), Ozyorsk, Chelyabinsk Region , Russia.
United States Transuranium and Uranium Registries (USTUR), College of Pharmacy, Washington State University, Richland, WA, USA.
Radiat Prot Dosimetry. 2017 Nov 1;176(1-2):117-131. doi: 10.1093/rpd/ncw239.
The method to estimate total skeleton plutonium burden of former Mayak Production Association (MPA) workers from limited bone samples obtained at autopsy is described. From two to nine bone samples were obtained at autopsies conducted from the mid-1950s to 2013. Plutonium was measured using alpha-radiometry up to 2000 and later by alpha-spectrometry. The method was validated using data from whole-body donations from the United States Transuranium and Uranium Registries (USTUR). The developed algorithm overestimated the USTUR values from 20 to 40%, that is quite acceptable for conservative estimation. Late-in-life liver diseases known to redistribute plutonium between liver and skeleton were not associated with significant differences in plutonium deposition among sampled bones, except for the pelvis. Sources of uncertainties are discussed and future studies will address the reduction of these uncertainties. This algorithm can be used to obtain data in support of the development of biokinetic, dosimetric and risk models for humans exposed to plutonium.
本文描述了一种根据在尸检时获取的有限骨骼样本估算前玛雅克生产协会（MPA）工人骨骼钚总负荷的方法。在1950年代中期至2013年进行的尸检中，获取了2至9个骨骼样本。2000年之前使用α辐射测量法测量钚，之后则采用α光谱法。该方法通过美国超铀和铀登记处（USTUR）全身捐赠的数据进行了验证。所开发的算法对USTUR值的高估幅度为20%至40%，对于保守估计而言这是完全可以接受的。已知会在肝脏和骨骼之间重新分布钚的晚年肝脏疾病，除骨盆外，在采样骨骼中的钚沉积方面并未显示出显著差异。文中讨论了不确定性来源，未来的研究将致力于减少这些不确定性。该算法可用于获取数据，以支持开发针对接触钚的人类的生物动力学、剂量学和风险模型。
