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儿童输尿管镜下激光碎石术中可取出碎片与粉末化处理的对比:前瞻性随机研究

Extractable fragment versus dusting during ureteroscopic laser lithotripsy in children: Prospective randomized study.

作者信息

Fahmy Ahmed, Youssif Mohamed, Rhashad Hazem, Orabi Samir, Mokless Ibrahim

机构信息

Department of Urology, Alexandria University, Alexandria, Egypt.

Department of Urology, Alexandria University, Alexandria, Egypt.

出版信息

J Pediatr Urol. 2016 Aug;12(4):254.e1-4. doi: 10.1016/j.jpurol.2016.04.037. Epub 2016 Jun 4.

Abstract

INTRODUCTION AND OBJECTIVES

Complete eradication of stone fragments is an important goal during stone management in children. The mode of fragmentation employed to clear stones during ureteroscopic laser lithotripsy raises concerns related to operative time, associated morbidity, costs, and especially potential endoscope damage. The purpose of this study was to evaluate the outcomes of fragmentation into extractable pieces and stone dusting during ureteroscopic laser lithotripsy in children.

MATERIAL AND METHODS

One hundred children with ureteral stones undergoing ureteroscopic holmium laser lithotripsy were prospectively randomized into two groups: group I in which stones were fragmented to dust (n = 50), and group II in which lithotripsy resulted in extractable fragments (n = 50). Different Holmium laser settings were applied during ureteroscopic lithotripsy for each group: low power (500 mJ) and high frequency (12-15 Hz) for lithotripsy to dust. High power (1000-1500 mJ) and reduced frequency (8-10 Hz) for lithotripsy to extractable fragments. The fragmentation time, operating time, stone-free rate, and perioperative complications were compared (Figure).

RESULTS

The mean age of the patients was 6.8 (1-12) years and 8.2 (1-15) years, in groups I and II respectively. The mean fragmentation time and operating time were statistically significantly lower in group II (p = 0.008 and 0.0069 respectively). Minor complications occurred in eight cases (5 in group I and 3 in group II) in the form of hematuria and urinary tract infection. No major complications were encountered in either groups.

CONCLUSIONS

Fragmenting stones into extractable pieces has a significantly shorter fragmentation time and operative time than stone dusting, with similar stone-free and complication rates. Ureteroscopic laser lithotripsy treatment resulting in extractable fragments seems to be an effective and time-saving procedure in children.

摘要

引言与目的

在儿童结石治疗过程中,彻底清除结石碎片是一个重要目标。输尿管镜激光碎石术中用于清除结石的碎石方式引发了对手术时间、相关发病率、成本,尤其是潜在内镜损伤的担忧。本研究的目的是评估儿童输尿管镜激光碎石术中碎成可取出碎片与结石粉末化的效果。

材料与方法

100例接受输尿管镜钬激光碎石术的输尿管结石患儿被前瞻性随机分为两组:第一组将结石碎成粉末(n = 50),第二组碎石后形成可取出的碎片(n = 50)。每组输尿管镜碎石术中采用不同的钬激光设置:碎成粉末的碎石术采用低能量(500 mJ)和高频率(12 - 15 Hz)。碎成可取出碎片的碎石术采用高能量(1000 - 1500 mJ)和较低频率(8 - 10 Hz)。比较两组的碎石时间、手术时间、结石清除率和围手术期并发症(图)。

结果

第一组和第二组患者的平均年龄分别为6.8(1 - 12)岁和8.2(1 - 15)岁。第二组的平均碎石时间和手术时间在统计学上显著更短(分别为p = 0.008和0.0069)。8例出现轻微并发症(第一组5例,第二组3例),表现为血尿和尿路感染。两组均未出现严重并发症。

结论

将结石碎成可取出的碎片比结石粉末化的碎石时间和手术时间显著更短,结石清除率和并发症发生率相似。输尿管镜激光碎石术治疗形成可取出的碎片似乎是一种对儿童有效且节省时间的手术方法。

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