Atkinson S D, Tuggle D W, Tunell W P
Department of Surgery, University of Oklahoma College of Medicine, Oklahoma City.
J Pediatr Surg. 1989 Jul;24(7):674-6. doi: 10.1016/s0022-3468(89)80717-1.
Numerous risk factors for necrotizing enterocolitis (NEC) including prematurity, bowel ischemia, pathogenic bacteria, and hyperosmolar feedings have been proposed. Recent studies have demonstrated feeding intolerance and bowel dysfunction in children with hypoalbuminemia. No association between hypoalbuminemia and NEC has been suggested. The records of 45 patients with NEC and complete documentation of prenatal and birth histories were reviewed. A control (CONT) group of 90 children matched for maternal age (+/- 1 year), parity, gestational age (+/- 1 week), birth weight (+/- 20 g), type of delivery, sex, race, type of initial feeding, and perinatal stress was compiled. While all other measured parameters were similar in the two groups, premorbid albumin was significantly lower in the patients who subsequently developed NEC (P less than .001). These data suggest that newborns with hypoalbuminemia may have an increased risk of developing NEC.
坏死性小肠结肠炎（NEC）的众多风险因素已被提出，包括早产、肠道缺血、病原菌和高渗喂养。最近的研究表明，低白蛋白血症患儿存在喂养不耐受和肠道功能障碍。尚未发现低白蛋白血症与NEC之间存在关联。回顾了45例患有NEC且有完整产前和出生史记录的患者。编制了一个由90名儿童组成的对照组（CONT），这些儿童在母亲年龄（±1岁）、产次、胎龄（±1周）、出生体重（±20克）、分娩类型、性别、种族、初始喂养类型和围产期应激方面相匹配。虽然两组的所有其他测量参数相似，但随后发生NEC的患者病前白蛋白水平显著较低（P小于0.001）。这些数据表明，低白蛋白血症的新生儿发生NEC的风险可能增加。
